PMID- 8672241 OWN - NLM STAT- MEDLINE DCOM- 19960812 LR - 20081121 IS - 1044-5498 (Print) IS - 1044-5498 (Linking) VI - 15 IP - 6 DP - 1996 Jun TI - Cloning and chromosomal mapping of bovine interleukin-2 receptor gamma gene. PG - 453-9 AB - Interleukin-2 receptor (IL-2R) gamma chain, a member of the cytokine receptor superfamily, forms a high-affinity receptor with IL-2R alpha and beta chains that plays an important role in interleukin-2 (IL-2) signal transduction. We have cloned and characterized the bovine IL-2Rgamma gene and corresponding cDNA. Bovine IL-2Rgamma is a single-copy gene that contains 8 exons and spans approximately 3.8 kb. The promoter region lacks conventional TATA and CCAAT consensus sites, but contains several regulatory elements that are recognition sites for the GATA binding proteins, AP-1 and AP-2. Physical assignment by fluorescence in situ hybridization (FISH) placed the bovine IL-2Rgamma gene on chromosome Xq23. FAU - Yoo, J AU - Yoo J AD - USDA, ARS, Roman L. Hruska U.S. Meat Animal Research Center (MARC), Clay Center, NE 68933-0166, USA. FAU - Stone, R T AU - Stone RT FAU - Solinas-Toldo, S AU - Solinas-Toldo S FAU - Fries, R AU - Fries R FAU - Beattie, C W AU - Beattie CW LA - eng SI - GENBANK/U33748 PT - Journal Article PL - United States TA - DNA Cell Biol JT - DNA and cell biology JID - 9004522 RN - 0 (DNA, Complementary) RN - 0 (DNA-Binding Proteins) RN - 0 (Receptors, Interleukin-2) RN - 0 (Transcription Factor AP-1) RN - 0 (Transcription Factor AP-2) RN - 0 (Transcription Factors) SB - IM MH - Amino Acid Sequence MH - Animals MH - Base Sequence MH - Binding Sites MH - Cattle MH - *Chromosome Mapping MH - Cloning, Molecular MH - DNA, Complementary/genetics MH - DNA-Binding Proteins/metabolism MH - Exons/genetics MH - Gene Dosage MH - Genes/*genetics MH - Molecular Sequence Data MH - Promoter Regions, Genetic/genetics MH - Receptors, Interleukin-2/*genetics MH - Transcription Factor AP-1/metabolism MH - Transcription Factor AP-2 MH - Transcription Factors/metabolism MH - X Chromosome/*genetics EDAT- 1996/06/01 00:00 MHDA- 1996/06/01 00:01 CRDT- 1996/06/01 00:00 PHST- 1996/06/01 00:00 [pubmed] PHST- 1996/06/01 00:01 [medline] PHST- 1996/06/01 00:00 [entrez] AID - 10.1089/dna.1996.15.453 [doi] PST - ppublish SO - DNA Cell Biol. 1996 Jun;15(6):453-9. doi: 10.1089/dna.1996.15.453.