PMID- 8673432
OWN - NLM
STAT- MEDLINE
DCOM- 19960812
LR  - 20161021
IS  - 1641-4640 (Print)
IS  - 1509-572X (Linking)
VI  - 33
IP  - 4
DP  - 1995
TI  - Rare vascular changes in the brain in a case of subacute cutaneous lupus 
      erythematosus.
PG  - 235-40
AB  - Histopathological changes in leptomeningeal and cerebral blood vessels in a case 
      of subacute cutaneous lupus erythematosus (SCLE) with the involvement of the 
      central nervous system are presented. A 46-year-old woman died because of 
      cerebral stroke after a 19-year duration of the disease. The general autopsy 
      showed changes in the kidneys, myocardium, spleen and pancreas, typical of 
      systemic lupus erythematosus. The brain autopsy revealed large necrosis in the 
      supply territory of the middle and posterior cerebral arteries in the left 
      hemisphere. In addition, small focal necroses, partially hemorrhagic, were found 
      in both cerebellar hemispheres. Small cortical necrosis was also visible in the 
      right insular area. A diffuse damage of the blood vascular system in the form of 
      fibrinoid necrosis of small sized cerebral blood vessels with inflammatory 
      infiltrates of the vessel wall (necrotizing leukocytoclastic vasculitis) 
      predominated in the microscopic examination of the brain. Vascular changes of 
      vasculopathy type in the form of hyalinization of the vascular wall and fibrinoid 
      necrosis with concomitant numerous, small necroses were observed. In the lumen of 
      left internal carotid artery infiltrated by inflammatory cells, an organized 
      thrombus was found. Giant cells were observed within vascular infiltration.
FAU - Bertrand, E
AU  - Bertrand E
AD  - Department of Neuropathology, Institute of Psychiatry and Neurology, Warszawa.
FAU - Kuczynska-Zardzewialy, A
AU  - Kuczynska-Zardzewialy A
FAU - Palasik, W
AU  - Palasik W
FAU - Chorzelski, T
AU  - Chorzelski T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Poland
TA  - Folia Neuropathol
JT  - Folia neuropathologica
JID - 9437431
SB  - IM
MH  - Arterioles/pathology
MH  - Capillaries/pathology
MH  - Cerebral Arteries/*pathology
MH  - Cerebral Infarction/pathology
MH  - Fatal Outcome
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/*pathology
MH  - Middle Aged
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
PST - ppublish
SO  - Folia Neuropathol. 1995;33(4):235-40.