PMID- 8675226
OWN - NLM
STAT- MEDLINE
DCOM- 19960815
LR  - 20221207
IS  - 0882-0139 (Print)
IS  - 0882-0139 (Linking)
VI  - 25
IP  - 1-2
DP  - 1996 Jan-Mar
TI  - HLA-DQ3 is associated with Graves' disease in African-Americans.
PG  - 103-10
AB  - HLA heterogeneity occurs in various ethnic groups and has been significantly 
      associated with Graves' disease. In this study we have determined that DQ3 is 
      associated with Graves' disease in African-Americans. Human leukocyte antigen 
      (HLA) typing of D-region antigens in 139 controls and 45 Graves' disease patients 
      reveals significant differences for HLA-DR2, DR9, DQ1, and DQ3. The latter 
      remained significant after correction. Increases in HLA-DR9 and DR3 are 
      associated with increases in DQ3 and DQ2, respectively. The decrease in DR2 is 
      associated with a decrease in DQ1. The associated increases and decreases in DR 
      with DQ antigens probably reflect linkage disequilibrium. Patients were evaluated 
      for autoantibodies against microsomal antigens and/or against thyroglobulin. All 
      of the normal control volunteers were negative for thyroid antibodies and 
      thirteen percent of patients produced autoantibodies. No significant associations 
      were detected for antibody production, type of treatment required, age of onset, 
      family history of Graves', status of T3, T4 levels, goiter and/or ophthalmopathy.
FAU - Ofosu, M H
AU  - Ofosu MH
AD  - Department of Biology, School of Arts & Sciences, Delaware State University, Luna 
      I Mishoe Science Center, Dover 19901, USA.
FAU - Dunston, G
AU  - Dunston G
FAU - Henry, L
AU  - Henry L
FAU - Ware, D
AU  - Ware D
FAU - Cheatham, W
AU  - Cheatham W
FAU - Brembridge, A
AU  - Brembridge A
FAU - Brown, C
AU  - Brown C
FAU - Alarif, L
AU  - Alarif L
LA  - eng
GR  - SO6-GM08182/GM/NIGMS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Immunol Invest
JT  - Immunological investigations
JID - 8504629
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ3 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Immunoglobulins, Thyroid-Stimulating)
RN  - 0 (Thyroid Hormones)
RN  - 0 (thyroid microsomal antibodies)
RN  - 9010-34-8 (Thyroglobulin)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Autoantibodies/blood
MH  - Autoimmune Diseases/blood/*ethnology/genetics/immunology
MH  - Black People/genetics
MH  - Disease Susceptibility
MH  - Female
MH  - Gene Frequency
MH  - Graves Disease/blood/*ethnology/genetics/immunology
MH  - HLA-DQ Antigens/*analysis/genetics
MH  - HLA-DR Antigens/analysis/genetics
MH  - Humans
MH  - Immunoglobulins, Thyroid-Stimulating/blood
MH  - Male
MH  - Middle Aged
MH  - Thyroglobulin/blood
MH  - Thyroid Hormones/blood
MH  - White People/genetics
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.3109/08820139609059294 [doi]
PST - ppublish
SO  - Immunol Invest. 1996 Jan-Mar;25(1-2):103-10. doi: 10.3109/08820139609059294.