PMID- 8675578
OWN - NLM
STAT- MEDLINE
DCOM- 19960815
LR  - 20111117
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 81
IP  - 7
DP  - 1996 Jul
TI  - Although DR3-DQB1*0201 may be associated with multiple component diseases of the 
      autoimmune polyglandular syndromes, the human leukocyte antigen DR4-DQB1*0302 
      haplotype is implicated only in beta-cell autoimmunity.
PG  - 2559-63
AB  - Human leukocyte antigen (HLA)-DRB1 and -DQB1 alleles were analyzed using a 
      PCR-based sequence-specific priming technique in 16 patients with autoimmune 
      polyglandular syndrome type I (APS-I), 31 patients with APS-II, and 110 patients 
      with component diseases of APS-II, including 9 patients with isolated Addison's 
      disease, 43 patients with Hashimoto's thyroiditis, 22 patients with Graves' 
      disease, and 36 patients with vitiligo. No significant associations was observed 
      between HLA and APS-I patients in our data set, nor was sharing of HLA haplotypes 
      by sibling pairs affected by APS I significantly different from the random 
      expectation. Thus, HLA-DRB1 and -DQB1 genes are probably not involved in APS-I. 
      To delineate the associations between HLA-DRB1, DQB1, and APS-II, we analyzed 
      APS-II patients with or without beta-cell autoimmunity [i.e. insulin-dependent 
      diabetes (IDD) and/or islet cell or glutamic acid decarboxylase autoantibodies]. 
      Our results suggest that the association between DR4-DQB1*0302 and APS-II was 
      entirely due to the presence of pancreatic beta-cell autoimmunity, since this 
      haplotype was otherwise not significantly associated with APS-II or with any 
      other of its component diseases. In contrast, the DR3-DQB1*0201 haplotype was 
      associated not only with IDD, but also with APS-II in the absence of pancreatic 
      beta-cell autoimmunity, as were several its component diseases, including 
      isolated Addison's disease, Graves' disease, and Hashimoto's thyroiditis. 
      Interestingly, the frequency of DQB1*0602, a dominantly protective allele against 
      IDD, was not significantly decreased in the APS-II patients with IDD or beta-cell 
      autoimmunity, albeit the patient numbers were small. This phenomenon may suggest 
      that the development of autoimmunity to nonpancreatic endocrine glands may 
      predispose autoimmunity to the pancreatic beta-cells and involve genes other than 
      those of the MHC.
FAU - Huang, W
AU  - Huang W
AD  - Department of Pathology, University of Florida College of Medicine, Gainesville 
      32610, USA.
FAU - Connor, E
AU  - Connor E
FAU - Rosa, T D
AU  - Rosa TD
FAU - Muir, A
AU  - Muir A
FAU - Schatz, D
AU  - Schatz D
FAU - Silverstein, J
AU  - Silverstein J
FAU - Crockett, S
AU  - Crockett S
FAU - She, J X
AU  - She JX
FAU - Maclaren, N K
AU  - Maclaren NK
LA  - eng
GR  - GCRC-RR-082./RR/NCRR NIH HHS/United States
GR  - HD-19469/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Autoimmune Diseases/genetics/*immunology
MH  - Child
MH  - HLA-DQ Antigens/*genetics/immunology
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics/immunology
MH  - HLA-DRB1 Chains
MH  - *Haplotypes
MH  - Humans
MH  - Islets of Langerhans/*immunology
MH  - Middle Aged
MH  - Polyendocrinopathies, Autoimmune/genetics/*immunology
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - 10.1210/jcem.81.7.8675578 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1996 Jul;81(7):2559-63. doi: 10.1210/jcem.81.7.8675578.