PMID- 8677736
OWN - NLM
STAT- MEDLINE
DCOM- 19960814
LR  - 20180216
IS  - 0001-5792 (Print)
IS  - 0001-5792 (Linking)
VI  - 95
IP  - 3-4
DP  - 1996
TI  - T cells, graft-versus-host disease and graft-versus-leukemia: innovative 
      approaches for blood and marrow transplantation.
PG  - 157-63
AB  - Allogeneic bone marrow transplantation is most commonly used as treatment for 
      leukemia. Allotransplantation is associated with several interrelated immunologic 
      processes, graft rejection, graft-versus-host disease (GvHD) and graft versus 
      leukemia (GvL). Graft rejection can be overcome by intensive pretransplant 
      immunosuppressive therapy. Following transplantation, immunoreconstitution must 
      occur from donor-derived progenitors and GvHD may occur from reactivity of 
      donor-derived immunocompetent cells against host tissues. In a related, but 
      distinct process, donor immunocompetent cells may react against the recipient 
      leukemia and recent data confirm that this GvL effect plays a critical role in 
      preventing posttransplant relapse. This report summarizes present data regarding 
      the mechanism of these processes. A major challenge is to separate the beneficial 
      GvL effect from GvHD, the major complication of allogeneic marrow 
      transplantation. We summarize data regarding innovative approaches to modify the 
      composition of the transplanted marrow to optimize clinical outcome as well as 
      use of donor lymphocyte infusions as a means to induce posttransplant GvL.
FAU - Champlin, R
AU  - Champlin R
AD  - Department of Hematology, University of Texas M.D. Anderson Cancer Center, 
      Houston 77030, USA.
FAU - Giralt, S
AU  - Giralt S
FAU - Gajewski, J
AU  - Gajewski J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Acta Haematol
JT  - Acta haematologica
JID - 0141053
SB  - IM
MH  - *Bone Marrow Transplantation/adverse effects/immunology
MH  - Graft Rejection
MH  - Graft vs Host Disease/*etiology/immunology
MH  - Humans
MH  - Leukemia/immunology/*therapy
MH  - Lymphocyte Depletion
MH  - Lymphocyte Transfusion
MH  - Lymphocytes/immunology
MH  - Recurrence
MH  - T-Lymphocytes/*immunology
MH  - Transplantation, Homologous/adverse effects/immunology
RF  - 67
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1159/000203871 [doi]
PST - ppublish
SO  - Acta Haematol. 1996;95(3-4):157-63. doi: 10.1159/000203871.