PMID- 8678766
OWN - NLM
STAT- MEDLINE
DCOM- 19960815
LR  - 20190704
IS  - 0004-0010 (Print)
IS  - 0004-0010 (Linking)
VI  - 131
IP  - 7
DP  - 1996 Jul
TI  - Adrenal lesions in a large kindred with multiple endocrine neoplasia type 1.
PG  - 699-702
AB  - OBJECTIVE: To review the prevalence and natural history of adrenal lesions 
      occurring in patients from a single kindred with multiple endocrine neoplasia 
      type 1 (MEN-1). DESIGN: Case series. SETTING: Tertiary referral center. PATIENTS: 
      Medical records of 33 patients from the Tasman 1 MEN-1 kindred who had undergone 
      abdominal computed tomographic (CT) scanning were reviewed. In 30 patients, the 
      results of abdominal ultrasonographic examinations were available for correlation 
      with CT scan. Computed tomographic and ultrasound scans of 18 patients were 
      reviewed by a radiologist blinded to the patients' clinical details. Three 
      patients underwent adrenalectomy, and the histopathologic material was reviewed. 
      MAIN OUTCOME MEASURES: Computed tomographic and ultrasound scans. RESULTS: 
      Adrenal lesions were detected in 12 patients (36%) by CT scan examination. 
      Ultrasound imaged 58% of these lesions. Pancreatic lesions were present in all 
      cases of adrenal disease. Follow-up was available for 8 patients with adrenal 
      disease. Over 5.5 years, 6 patients (75%) had stable disease, 1 patient had an 
      adrenal lesion that enlarged by 5 mm, and 1 patient had a lesion that enlarged by 
      50 mm. Adrenal histopathologic material was available in 3 patients. Macronodular 
      cortical hyperplasia was present in 2 patients and a cortical adenoma present in 
      1 patient. Another kindred had bilateral macronodular cortical hyperplasia at 
      autopsy. CONCLUSIONS: Adrenal lesions are common in MEN-1 and occur in 
      association with pancreatic disease. Abdominal CT scan is more sensitive than 
      ultrasonographic examination in detecting adrenal disease. Primary hypersecretory 
      syndromes of the adrenal glands appear to be rare, and the majority of lesions 
      follow an indolent clinical course.
FAU - Burgess, J R
AU  - Burgess JR
AD  - Department of Diabetes and Endocrine Services, Royal Hobart Hospital, Australia.
FAU - Harle, R A
AU  - Harle RA
FAU - Tucker, P
AU  - Tucker P
FAU - Parameswaran, V
AU  - Parameswaran V
FAU - Davies, P
AU  - Davies P
FAU - Greenaway, T M
AU  - Greenaway TM
FAU - Shepherd, J J
AU  - Shepherd JJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Surg
JT  - Archives of surgery (Chicago, Ill. : 1960)
JID - 9716528
SB  - IM
MH  - Adrenal Gland Neoplasms/diagnosis/*genetics/pathology
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*genetics/pathology
MH  - Pancreatic Neoplasms/diagnosis/genetics
MH  - Sensitivity and Specificity
MH  - Tomography, X-Ray Computed
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - 10.1001/archsurg.1996.01430190021006 [doi]
PST - ppublish
SO  - Arch Surg. 1996 Jul;131(7):699-702. doi: 10.1001/archsurg.1996.01430190021006.