PMID- 8680129
OWN - NLM
STAT- MEDLINE
DCOM- 19960821
LR  - 20161123
IS  - 0887-7971 (Print)
IS  - 0887-7971 (Linking)
VI  - 10
IP  - 1
DP  - 1996 Jan
TI  - Abnormalities of cardiac sympathetic neuronal and left ventricular function in 
      chronic mitral regurgitation: assessment by iodine-123 metaiodobenzylguanidine 
      scintigraphy.
PG  - 14-22
AB  - Myocardial uptake of iodine-123 meta-iodobenzylguanidine (123I-MIBG) was measured 
      using scintigrams at rest in 12 patients with isolated, nonischemic mitral 
      regurgitation (MR; regurgitant fraction 64% +/- 7%) and was related to the left 
      ventricular (LV) function assessed by cardiac catheterization. Iodine-123 
      meta-iodobenzylguanidine activity in the upper mediastinum, liver, and lung was 
      comparable between MR and control (n = 8) patients. The heart-to-mediastinum 
      123I-MIBG activity ratio 4 hours after injection was significantly (p < 0.01) 
      decreased in MR (2.0 +/- 0.1, mean +/- SE) compared with control (2.7 +/- 0.1) 
      with the increased clearance of MIBG. In addition, MR patients had significantly 
      greater heterogeneity in the 123I-MIBG distribution within the myocardial images 
      (26.1% +/- 2.1% intraimage variability for MR versus 15.6% +/- 0.8% for control, 
      p < 0.01). Myocardial 123I-MIBG activity correlated positively with cardiac index 
      and negatively with pulmonary capillary wedge pressure and LV volume indexes. 
      Thus, 123I-MIBG scintigrams can be a noninvasive method for assessing the 
      contractile dysfunction in MR.
FAU - Tsutsui, H
AU  - Tsutsui H
AD  - Research Institute of Angiocardiology, Faculty of Medicine, Kyushu University, 
      Fukuoka, Japan.
FAU - Ando, S
AU  - Ando S
FAU - Kubota, T
AU  - Kubota T
FAU - Kuroiwa-Matsumoto, M
AU  - Kuroiwa-Matsumoto M
FAU - Egashira, K
AU  - Egashira K
FAU - Sasaki, M
AU  - Sasaki M
FAU - Kuwabara, Y
AU  - Kuwabara Y
FAU - Koyanagi, S
AU  - Koyanagi S
FAU - Yasui, H
AU  - Yasui H
FAU - Takeshita, A
AU  - Takeshita A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Card Imaging
JT  - American journal of cardiac imaging
JID - 8706659
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Iodobenzenes)
RN  - 0 (Thallium Radioisotopes)
RN  - 35MRW7B4AD (3-Iodobenzylguanidine)
SB  - IM
MH  - 3-Iodobenzylguanidine
MH  - Cardiac Catheterization
MH  - Case-Control Studies
MH  - Female
MH  - Heart/*diagnostic imaging/*innervation
MH  - Humans
MH  - *Iodine Radioisotopes
MH  - *Iodobenzenes
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve Insufficiency/complications/*diagnostic imaging/physiopathology
MH  - Myocardial Contraction/physiology
MH  - Sympathetic Nervous System/physiopathology
MH  - Thallium Radioisotopes
MH  - Time Factors
MH  - Tomography, Emission-Computed, Single-Photon
MH  - Ventricular Dysfunction, Left/*diagnostic imaging/etiology/physiopathology
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
PST - ppublish
SO  - Am J Card Imaging. 1996 Jan;10(1):14-22.