PMID- 8682590
OWN - NLM
STAT- MEDLINE
DCOM- 19960822
LR  - 20160303
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 69
IP  - 3
DP  - 1996 Jun 21
TI  - Overexpression of the met/HGF receptor in renal cell carcinomas.
PG  - 212-7
AB  - The c-met oncogene encodes the receptor for hepatocyte growth factor/scatter 
      factor (HGF/SF), a multifunctional cytokine able to mediate morphogenesis as well 
      as mitogenesis, motogenesis and invasiveness of epithelial cells. HGF/SF has been 
      implicated in branching tubulogenesis of the developing kidney and in 
      regeneration after renal injury and nephrectomy. We have examined the expression 
      of the met/HGF receptor in normal human kidney and tissues of the genito-urinary 
      tract, and in 50 kidney neoplasms of different histotypes, using monoclonal 
      antibodies (MAbs) against the met/HGF receptor and immunohistochemistry. In 
      normal kidneys, weak staining restricted to the distal tubules was observed. 
      Transitional cell carcinomas were consistently negative, whereas increased 
      expression at various levels was found in 87% of renal cell carcinomas with 
      different cytological features and histological patterns. Western blot analysis 
      of samples showed that the met/HGF receptor found in the malignant cells exhibits 
      features of the normal receptor. The met/HGF receptor is also overexpressed in a 
      renal cell carcinoma cell line, whose motility is triggered by HGF/SF. Our data 
      suggest that expression of the met/HGF receptor may be involved in the onset and 
      progression of renal cell carcinomas.
FAU - Natali, P G
AU  - Natali PG
AD  - Regina Elena Cancer Research Institute, Rome, Italy.
FAU - Prat, M
AU  - Prat M
FAU - Nicotra, M R
AU  - Nicotra MR
FAU - Bigotti, A
AU  - Bigotti A
FAU - Olivero, M
AU  - Olivero M
FAU - Comoglio, P M
AU  - Comoglio PM
FAU - Di Renzo, M F
AU  - Di Renzo MF
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Antibodies, Monoclonal)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Antibodies, Monoclonal
MH  - Carcinoma, Renal Cell/genetics/metabolism/*ultrastructure
MH  - Cell Line, Transformed
MH  - Gene Expression
MH  - Hepatocyte Growth Factor/analysis
MH  - Humans
MH  - Immunohistochemistry
MH  - Kidney/ultrastructure
MH  - Kidney Neoplasms/genetics/metabolism/*ultrastructure
MH  - Kidney Tubules/ultrastructure
MH  - Proto-Oncogene Proteins c-met
MH  - Receptor Protein-Tyrosine Kinases/*analysis/biosynthesis/genetics
MH  - Reference Values
MH  - Tumor Cells, Cultured
MH  - Urogenital System/ultrastructure
EDAT- 1996/06/21 00:00
MHDA- 2000/06/20 09:00
CRDT- 1996/06/21 00:00
PHST- 1996/06/21 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1996/06/21 00:00 [entrez]
AID - 10.1002/(SICI)1097-0215(19960621)69:3<212::AID-IJC11>3.0.CO;2-9 [pii]
AID - 10.1002/(SICI)1097-0215(19960621)69:3<212::AID-IJC11>3.0.CO;2-9 [doi]
PST - ppublish
SO  - Int J Cancer. 1996 Jun 21;69(3):212-7. doi: 
      10.1002/(SICI)1097-0215(19960621)69:3<212::AID-IJC11>3.0.CO;2-9.