PMID- 8686102
OWN - NLM
STAT- MEDLINE
DCOM- 19960821
LR  - 20181113
IS  - 0041-6193 (Print)
IS  - 0041-6193 (Linking)
VI  - 65
IP  - 1
DP  - 1996 May
TI  - Antineutrophil cytoplasmic antibodies in myelodysplasia.
PG  - 55-7
AB  - Antibodies to neutrophil cytoplasmic antigens (ANCA) are good serological markers 
      for patients with mainly vasculitic conditions. Two main types of ANCAs have been 
      detected, the first termed cytoplasmic antineutrophil cytoplasmic antibody 
      (cANCA) are mainly associated with patients with Wegener's granulomatosis, the 
      other termed perinuclear antineutrophil cytoplasmic antibody (pANCA) are mainly 
      associated with patients with renal vasculitis, rheumatic and collagen disorders. 
      These antibodies are against various constituents of neutrophil granules. In 
      patients with myelodysplasia, defects in normal granulocyte development are seen. 
      We report a series of twelve patients with myelodysplasia of whom at least four 
      showed a low titre and one a high titre of pANCA. Two of these patients also had 
      demonstrable activity against myeloperoxidase (MPO). None of these patients had 
      any evidence of systemic or cutaneous vasculitis or of any autoimmune disorder. 
      There was no pANCA positivity in an age matched control group.
FAU - Hull, D R
AU  - Hull DR
AD  - Department of Haematology, Royal Victoria Hospital, Belfast.
FAU - McMillan, S A
AU  - McMillan SA
FAU - Rea, I M
AU  - Rea IM
FAU - Boyd, N
AU  - Boyd N
FAU - McMullin, M F
AU  - McMullin MF
LA  - eng
PT  - Journal Article
PL  - Northern Ireland
TA  - Ulster Med J
JT  - The Ulster medical journal
JID - 0417367
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - Autoantibodies/*blood
MH  - *Biomarkers
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*diagnosis/immunology
MH  - Neutrophils/immunology
MH  - Peroxidase/immunology
MH  - Reference Values
PMC - PMC2448746
EDAT- 1996/05/01 00:00
MHDA- 1996/05/01 00:01
PMCR- 1996/07/01
CRDT- 1996/05/01 00:00
PHST- 1996/05/01 00:00 [pubmed]
PHST- 1996/05/01 00:01 [medline]
PHST- 1996/05/01 00:00 [entrez]
PHST- 1996/07/01 00:00 [pmc-release]
PST - ppublish
SO  - Ulster Med J. 1996 May;65(1):55-7.