PMID- 8689608
OWN - NLM
STAT- MEDLINE
DCOM- 19960829
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 89
IP  - 1
DP  - 1996 Jul 1
TI  - Genotypic characterization of a primary mucoepidermoid carcinoma of the parotid 
      gland by cytogenetic, fluorescence in situ hybridization, and DNA ploidy 
      analysis.
PG  - 38-43
AB  - We present a case of mucoepidermoid carcinoma with t(3;12)(q24;p13) and polysomy 
      X by cytogenetic and fluorescence in situ hybridization (FISH) techniques. Flow 
      cytometric DNA analysis of the primary tumor showed DNA aneuploidy and analysis 
      of cultured tumor cells showed DNA diploidy indicating restricted growth of the 
      diploid tumor cells in short-term tissue culture. Interphase cytogenetic analysis 
      of chromosomes 1, 3, 6-12, 16-18, and X in the primary tumor showed polysomy 1, 
      9, 18, and X, monosomy 8 and 17, and disomy 3, 6, 7, 10-12, and 16. Except for 
      chromosome X, other numerical chromosomal abnormalities were not detected by 
      conventional cytogenetic analysis. Our combined approach allowed for better 
      characterization of the genotypic features of this neoplasm.
FAU - el-Naggar, A K
AU  - el-Naggar AK
AD  - Department of Pathology, University of Texas, Houston 77030, USA.
FAU - Lovell, M
AU  - Lovell M
FAU - Killary, A M
AU  - Killary AM
FAU - Batsakis, J G
AU  - Batsakis JG
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Aged
MH  - Carcinoma, Mucoepidermoid/*genetics/pathology
MH  - *Chromosome Aberrations
MH  - DNA, Neoplasm/*analysis
MH  - Female
MH  - Flow Cytometry
MH  - Genotype
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Parotid Neoplasms/*genetics/pathology
MH  - *Ploidies
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - 0165460896000325 [pii]
AID - 10.1016/0165-4608(96)00032-5 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1996 Jul 1;89(1):38-43. doi: 
      10.1016/0165-4608(96)00032-5.