PMID- 8689609
OWN - NLM
STAT- MEDLINE
DCOM- 19960829
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 89
IP  - 1
DP  - 1996 Jul 1
TI  - Tetrasomy 8 in a patient with acute nonlymphocytic leukemia: a metaphase and 
      interphase study with fluorescence in situ hybridization.
PG  - 44-8
AB  - Tetrasomy 8 constitutes a relatively rare recurring chromosome defect in myeloid 
      disorders. The patient reported here, a 71-year-old man, presented with tetrasomy 
      8 as the sole chromosome abnormality associated with an acute nonlymphocytic 
      leukemia of the M2 type. He failed to respond to chemotherapy and died one year 
      after diagnosis. Following conventional cytogenetics and fluorescence in situ 
      hybridization (FISH) with a centromeric probe specific for chromosome 8, 
      tetrasomy 8 was detected in 61% of the metaphases analyzed and trisomy 8 in 39%. 
      FISH analysis of interphase nuclei confirmed the existence of tetrasomic (35%) 
      and trisomic cells (56%) and revealed a number of cells with two chromosomes 8 
      (8%). This normal population may represent lymphocytes or myeloid cells that 
      escaped conventional analysis due to their inability to divide or to the small 
      number of metaphases available. The relatively higher proportion of tetrasomic 
      cells in metaphase compared with interphase may be attributed to a proliferative 
      advantage of tetrasomic cells in vitro or to the longer duration of their cell 
      cycle. The simultaneous presence of trisomic and tetrasomic cells confirms the 
      hypothesis of a clonal relationship between trisomy 8 and tetrasomy 8. Our case 
      brings further evidence to the specificity of tetrasomy 8 to myeloid disorders 
      and to the association of this chromosome abnormality with a relatively poor 
      prognosis. However, new patients must be studied to further delineate this 
      cytogenetic entity.
FAU - Muhlematter, D
AU  - Muhlematter D
AD  - Division Autonome de Genetique Medicale, Centre Hospitalier Universitaire Vaudois 
      CHUV, Lausanne, Switzerland.
FAU - Castagne, C
AU  - Castagne C
FAU - Bruzzese, O
AU  - Bruzzese O
FAU - Clement, F
AU  - Clement F
FAU - Schmidt, P M
AU  - Schmidt PM
FAU - Bellomo, M J
AU  - Bellomo MJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Aged
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 8
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Interphase
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - Metaphase
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - 0165460895003436 [pii]
AID - 10.1016/0165-4608(95)00343-6 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1996 Jul 1;89(1):44-8. doi: 10.1016/0165-4608(95)00343-6.