PMID- 8690318
OWN - NLM
STAT- MEDLINE
DCOM- 19960829
LR  - 20201209
IS  - 0278-6915 (Print)
IS  - 0278-6915 (Linking)
VI  - 34
IP  - 6
DP  - 1996 Jun
TI  - Experimental assessment of the sensitizing properties of formaldehyde.
PG  - 571-8
AB  - Formaldehyde causes upper respiratory tract irritation and has been reported in 
      some investigations to be a cause of occupational allergic asthma. The data are 
      equivocal, however, and it has proved difficult to confirm that exposure to 
      formaldehyde induces respiratory sensitization or provokes the production of 
      specific immunoglobulin E (IgE) antibody. In this study the sensitizing 
      properties of formaldehyde were examined experimentally. This chemical elicited 
      strong positive responses in three independent methods for the prospective 
      identification of contact sensitizing chemicals-the guinea pig maximization test, 
      the occluded patch test of Buehler and the murine local lymph node assay. In 
      contrast, in a novel predictive test method for assessment of respiratory 
      sensitization potential-the mouse IgE test-formaldehyde at the same test 
      concentrations was negative. Furthermore, formaldehyde induced in mice a pattern 
      of cytokine secretion by draining lymph node cells inconsistent with the 
      stimulation of IgE antibody responses or respiratory sensitization. These data 
      indicate that, although formaldehyde is a potent contact allergen, it lacks a 
      significant potential to cause sensitization of the respiratory tract.
FAU - Hilton, J
AU  - Hilton J
AD  - Zeneca Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK.
FAU - Dearman, R J
AU  - Dearman RJ
FAU - Basketter, D A
AU  - Basketter DA
FAU - Scholes, E W
AU  - Scholes EW
FAU - Kimber, I
AU  - Kimber I
LA  - eng
PT  - Journal Article
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Allergens)
RN  - 0 (Cytokines)
RN  - 0 (Dinitrochlorobenzene)
RN  - 0 (Irritants)
RN  - 0 (Phthalic Anhydrides)
RN  - 130068-27-8 (Interleukin-10)
RN  - 1HG84L3525 (Formaldehyde)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 80T61EUU7H (trimellitic anhydride)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Administration, Topical
MH  - Allergens/*toxicity
MH  - Animals
MH  - Cytokines/drug effects/metabolism
MH  - Dermatitis, Allergic Contact/*etiology/immunology
MH  - Dinitrochlorobenzene/toxicity
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Formaldehyde/administration & dosage/*toxicity
MH  - Guinea Pigs
MH  - Immunoglobulin E/drug effects
MH  - Interferon-gamma/biosynthesis/drug effects
MH  - Interleukin-10/biosynthesis
MH  - Irritants/toxicity
MH  - Lymph Nodes/drug effects
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Patch Tests/methods
MH  - Phthalic Anhydrides/toxicity
EDAT- 1996/06/01 00:00
MHDA- 1996/06/01 00:01
CRDT- 1996/06/01 00:00
PHST- 1996/06/01 00:00 [pubmed]
PHST- 1996/06/01 00:01 [medline]
PHST- 1996/06/01 00:00 [entrez]
AID - 0278-6915(96)00012-9 [pii]
AID - 10.1016/0278-6915(96)00012-9 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 1996 Jun;34(6):571-8. doi: 10.1016/0278-6915(96)00012-9.