PMID- 8690455
OWN - NLM
STAT- MEDLINE
DCOM- 19960829
LR  - 20190512
IS  - 0019-2805 (Print)
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Linking)
VI  - 88
IP  - 2
DP  - 1996 Jun
TI  - Sensitization of T-cell receptor-alpha beta+ T cells recovered from long-term 
      T-cell receptor downmodulation.
PG  - 230-7
AB  - Although the survival of fully allogeneic skin grafts was prominently prolonged 
      by adult thymectomy in anti-T-cell receptor-alpha beta monoclonal antibody 
      (TCR-alpha beta mAb)-treated mice compared with that of non-adult thymectomized 
      (ATX) mice, the skin allografts were eventually rejected. In the anti-TCR-alpha 
      beta mAb-treated ATX mice, as shown in the present study, most of TCR-alpha beta+ 
      cells were promptly activated on day 2 and then rapidly disappeared by day 7, but 
      some TCR-alpha beta- Thy-1+ cells remained at that time. These TCR-alpha beta- 
      Thy-1+ cells which have downmodulated their TCR-alpha beta expression may be 
      refractory to depletion events by the mAb treatment. Although these downmodulated 
      T cells re-expressed their TCR-alpha beta on day 50, they could not respond to 
      stimuli via TCR such as TCR cross-linking or alloantigens. However, they 
      recovered the reactivity to donor antigens on day 85. These results indicate that 
      the downmodulated T cells by anti-TCR-alpha beta mAb treatment are long-lived and 
      re-express their TCR-alpha beta at a late stage to be sensitized to donor 
      antigen, which suggests that additional regimens may be required to get 
      permanent, or very long-term, graft acceptance.
FAU - Omoto, K
AU  - Omoto K
AD  - Department of Immunology, Kyushu University, Fukuoka, Japan.
FAU - Kong, Y Y
AU  - Kong YY
FAU - Nomoto, K
AU  - Nomoto K
FAU - Umesue, M
AU  - Umesue M
FAU - Murakami, Y
AU  - Murakami Y
FAU - Eto, M
AU  - Eto M
FAU - Nomoto, K
AU  - Nomoto K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
SB  - IM
MH  - Animals
MH  - Antigenic Modulation
MH  - Down-Regulation
MH  - Female
MH  - Graft Rejection/*immunology/prevention & control
MH  - Immunotherapy, Adoptive
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Receptors, Antigen, T-Cell, alpha-beta/*immunology
MH  - Skin Transplantation/*immunology
MH  - T-Lymphocytes/*immunology
MH  - Thymectomy
MH  - Time Factors
MH  - Transplantation, Homologous
PMC - PMC1456440
EDAT- 1996/06/01 00:00
MHDA- 1996/06/01 00:01
PMCR- 1997/06/01
CRDT- 1996/06/01 00:00
PHST- 1996/06/01 00:00 [pubmed]
PHST- 1996/06/01 00:01 [medline]
PHST- 1996/06/01 00:00 [entrez]
PHST- 1997/06/01 00:00 [pmc-release]
AID - 10.1111/j.1365-2567.1996.tb00009.x [doi]
PST - ppublish
SO  - Immunology. 1996 Jun;88(2):230-7. doi: 10.1111/j.1365-2567.1996.tb00009.x.