PMID- 8692887
OWN - NLM
STAT- MEDLINE
DCOM- 19960823
LR  - 20220317
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 93
IP  - 13
DP  - 1996 Jun 25
TI  - Characterization of a murine Ahr null allele: involvement of the Ah receptor in 
      hepatic growth and development.
PG  - 6731-6
AB  - The Ah receptor (AHR) is a ligand-activated transcription factor that mediates a 
      pleiotropic response to environmental contaminants such as benzo[a]pyrene and 
      2,3,7,8-tetrachlorodibenzo-p-dioxin. In an effort to gain insight into the 
      physiological role of the AHR and to develop models useful in risk assessment, 
      gene targeting was used to inactivate the murine Ahr gene by homologous 
      recombination. Ahr-/- mice are viable and fertile but show a spectrum of hepatic 
      defects that indicate a role for the AHR in normal liver growth and development. 
      The Ahr-/- phenotype is most severe between 0-3 weeks of age and involves slowed 
      early growth and hepatic defects, including reduced liver weight, transient 
      microvesicular fatty metamorphosis, prolonged extramedullary hematopoiesis, and 
      portal hypercellularity with thickening and fibrosis.
FAU - Schmidt, J V
AU  - Schmidt JV
AD  - Department of Molecular Pharmacology, Northwestern University Medical School, 
      Chicago, IL 60611, USA.
FAU - Su, G H
AU  - Su GH
FAU - Reddy, J K
AU  - Reddy JK
FAU - Simon, M C
AU  - Simon MC
FAU - Bradfield, C A
AU  - Bradfield CA
LA  - eng
GR  - CA09560/CA/NCI NIH HHS/United States
GR  - ES06883/ES/NIEHS NIH HHS/United States
GR  - HL52094-01/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Receptors, Aryl Hydrocarbon)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
SB  - IM
MH  - *Alleles
MH  - Animals
MH  - Cell Line
MH  - Cytochrome P-450 Enzyme System/biosynthesis
MH  - Female
MH  - Gene Targeting
MH  - Liver/drug effects/*embryology/enzymology/pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Phenotype
MH  - Polychlorinated Dibenzodioxins/toxicity
MH  - Receptors, Aryl Hydrocarbon/genetics/*physiology
PMC - PMC39095
EDAT- 1996/06/25 00:00
MHDA- 1996/06/25 00:01
PMCR- 1996/12/25
CRDT- 1996/06/25 00:00
PHST- 1996/06/25 00:00 [pubmed]
PHST- 1996/06/25 00:01 [medline]
PHST- 1996/06/25 00:00 [entrez]
PHST- 1996/12/25 00:00 [pmc-release]
AID - 10.1073/pnas.93.13.6731 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6731-6. doi: 
      10.1073/pnas.93.13.6731.