PMID- 8692964
OWN - NLM
STAT- MEDLINE
DCOM- 19960829
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 93
IP  - 14
DP  - 1996 Jul 9
TI  - Interleukin 7 receptor-deficient mice lack gammadelta T cells.
PG  - 7172-7
AB  - The interleukin 7 receptor (IL-7R) plays a crucial role in early B- and T-cell 
      development. It consists of a unique a chain and a common gamma chain [IL-2 
      receptor gamma chain (IL-2Rgamma)]. Gene inactivation of IL-7, IL-7R, and 
      IL-2Rgamma resulted in severe impairment of B and T lymphopoiesis in mice. In 
      addition, IL-2Rgamma-deficient mice lack gammadelta T cells in the skin and have 
      the impaired development of natural killer (NK) cells and intraepithelial 
      lymphocytes. To explore the role of IL-7/IL-7R system in gammadelta T- and 
      NK-cell development, we have generated and analyzed IL-7R-deficient mice. 
      gammadelta T cells were absent from skin, gut, liver, and spleen in the deficient 
      mice. In contrast, alphabeta T and B cells were detected in reduced, but certain, 
      numbers, and NK cells developed normally. The gammadelta T-cell development in 
      fetal and adult thymus was also completely blocked. These results clearly 
      demonstrate that the signal from IL-7R is indispensable for gammadelta T-cell 
      development in both thymic and extrathymic pathways. On the contrary, it is 
      suggested that NK-cell development requires cytokine(s) other than IL-7.
FAU - Maki, K
AU  - Maki K
AD  - Department of Disease-Related Gene Regulation Research (Sandoz) Faculty of 
      Medicine, The Univerisity of Tokyo, Japan.
FAU - Sunaga, S
AU  - Sunaga S
FAU - Komagata, Y
AU  - Komagata Y
FAU - Kodaira, Y
AU  - Kodaira Y
FAU - Mabuchi, A
AU  - Mabuchi A
FAU - Karasuyama, H
AU  - Karasuyama H
FAU - Yokomuro, K
AU  - Yokomuro K
FAU - Miyazaki, J I
AU  - Miyazaki JI
FAU - Ikuta, K
AU  - Ikuta K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Antigens, CD)
RN  - 0 (DNA Primers)
RN  - 0 (Receptors, Antigen, T-Cell, gamma-delta)
RN  - 0 (Receptors, Interleukin)
RN  - 0 (Receptors, Interleukin-7)
SB  - IM
MH  - Animals
MH  - Antigens, CD/*genetics/*physiology
MH  - B-Lymphocytes/immunology
MH  - Base Sequence
MH  - Crosses, Genetic
MH  - DNA Primers
MH  - Embryo, Mammalian
MH  - Flow Cytometry
MH  - Genomic Library
MH  - Immunologic Deficiency Syndromes/genetics/immunology
MH  - Intestines/immunology
MH  - Killer Cells, Natural/*immunology
MH  - Liver/immunology
MH  - Lymphocytes/immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred Strains
MH  - Mice, Mutant Strains
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - *Receptors, Antigen, T-Cell, gamma-delta
MH  - Receptors, Interleukin/*genetics/*physiology
MH  - Receptors, Interleukin-7
MH  - Restriction Mapping
MH  - Skin/immunology
MH  - Spleen/immunology
MH  - Stem Cells
MH  - T-Lymphocytes/*immunology
PMC - PMC38955
EDAT- 1996/07/09 00:00
MHDA- 1996/07/09 00:01
PMCR- 1997/01/09
CRDT- 1996/07/09 00:00
PHST- 1996/07/09 00:00 [pubmed]
PHST- 1996/07/09 00:01 [medline]
PHST- 1996/07/09 00:00 [entrez]
PHST- 1997/01/09 00:00 [pmc-release]
AID - 10.1073/pnas.93.14.7172 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7172-7. doi: 10.1073/pnas.93.14.7172.