PMID- 8695722
OWN - NLM
STAT- MEDLINE
DCOM- 19960904
LR  - 20190920
IS  - 0939-5555 (Print)
IS  - 0939-5555 (Linking)
VI  - 73
IP  - 1
DP  - 1996 Jul
TI  - Progression of a myelodysplastic syndrome to pre-B acute lymphoblastic leukemia: 
      a case report and cell lineage study.
PG  - 35-8
AB  - The evolution of acute lymphoblastic leukemia from a myelodysplastic syndrome is 
      a very uncommon event. We describe a 46-year-old man in whom refractory anemia 
      with excess blasts (RAEB) evolved to a pre-B acute lymphocytic leukemia. Trisomy 
      8 was one of the cytogenetic abnormalities in the dysplastic clone and was 
      detected in both peripheral blood and bone marrow smears of interphase cells by 
      the fluorescence in situ hybridization (FISH) technique. Using a chromosome 8 
      centromeric specific DNA probe we identified the trisomy 8 to be present in 
      lymphoblasts, erythroid precursors, myeloblasts, promyelocytes, myelocytes, 
      metamyelocytes, granulocytes, and monocytes. Our case supports the hypothesis 
      that in MDS the pluripotent precursor cell is affected, and we examine the 
      potential role of FISH for the study and follow-up of some hematological 
      diseases.
FAU - Abruzzese, E
AU  - Abruzzese E
AD  - Department of Pediatrics, Bowman Gray School of Medicine, Winston Salem, NC 
      27157-1076, USA.
FAU - Buss, D
AU  - Buss D
FAU - Rainer, R
AU  - Rainer R
FAU - Pettenati, M J
AU  - Pettenati MJ
FAU - Rao, P N
AU  - Rao PN
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - Ann Hematol
JT  - Annals of hematology
JID - 9107334
RN  - 0 (Antigens, Surface)
SB  - IM
MH  - Antigens, Surface/analysis
MH  - Burkitt Lymphoma/*pathology
MH  - Chromosome Aberrations/pathology
MH  - Chromosome Disorders
MH  - Chromosomes, Human, Pair 8
MH  - Clone Cells
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*pathology
MH  - Preleukemia/*pathology
MH  - Time Factors
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - 10.1007/s002770050197 [doi]
PST - ppublish
SO  - Ann Hematol. 1996 Jul;73(1):35-8. doi: 10.1007/s002770050197.