PMID- 8696077
OWN - NLM
STAT- MEDLINE
DCOM- 19960904
LR  - 20191101
IS  - 0966-0844 (Print)
IS  - 0966-0844 (Linking)
VI  - 9
IP  - 3
DP  - 1996 Jul
TI  - Antitumor activity of titanocene amino acid complexes.
PG  - 267-71
AB  - Seven ionic titanocene alpha-amino acid (aa) complexes [(C5H5)2Ti(aa)2]2+[X]2- 
      with aa = glycine, L-alanine, 2-methylalanine, D-L-phenylalanine, 
      D,L-4-fluorophenylalanine and X = Cl or AsF6, were investigated for antitumor 
      activity against fluid Ehrlich ascites tumor growing in CF1 mice. These complexes 
      are the first stable model compounds of titanocene units with protein components, 
      synthesized from a water-like, methanolic medium. All titanocene amino acid 
      complexes induced antitumor activity which was manifested by maximum cure rates 
      ranging from 30 to 70% and increases in life span from 78 to 276% in comparison 
      with untreated control animals. The complexes containing chloride as anion X were 
      more effective than the hexafluoroarsenate derivatives, which surprisingly showed 
      a low substance toxicity. In all cases, the antitumor activity of the ionic 
      titanocene amino acid complexes tested was less pronounced than that of the 
      neutral parent compound [(C5H5)2TiCl2].
FAU - Kopf-Maier, P
AU  - Kopf-Maier P
AD  - Institut fur Anatomie, Freie Universitat Berlin, Germany.
FAU - Tornieporth-Oetting, I C
AU  - Tornieporth-Oetting IC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Biometals
JT  - Biometals : an international journal on the role of metal ions in biology, 
      biochemistry, and medicine
JID - 9208478
RN  - 0 (Amino Acids)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Organometallic Compounds)
SB  - IM
MH  - Amino Acids/*chemistry
MH  - Animals
MH  - Antineoplastic Agents/*pharmacology
MH  - Biological Assay
MH  - Carcinoma, Ehrlich Tumor/*drug therapy
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Mice
MH  - Models, Molecular
MH  - Organometallic Compounds/*pharmacology
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - 10.1007/BF00817926 [doi]
PST - ppublish
SO  - Biometals. 1996 Jul;9(3):267-71. doi: 10.1007/BF00817926.