PMID- 8696422
OWN - NLM
STAT- MEDLINE
DCOM- 19960905
LR  - 20140603
VI  - 20
IP  - 5
DP  - 1996 May
TI  - Covert manipulation of the ratio of medium- to long-chain triglycerides in 
      isoenergetically dense diets: effect on food intake in ad libitum feeding men.
PG  - 435-44
AB  - OBJECTIVE: This study examined whether isoenergetic substitution of MCT for LCT 
      in HF, HE diets (639 kJ/100 g) limits the excess energy intakes frequently 
      observed on high-fat diets of high energy density (HF, HE). SUBJECTS: Six healthy 
      male volunteers [mean age (SD) = 27.17 (4.17 y) mean weight = 63.33 (7.33 kg), 
      mean height = 1.72 (0.05 m)]. DESIGN: The subjects were each studied three times 
      during 14 d throughout which they had ad libitum access to one of three 
      covertly-manipulated diets, which were randomly assigned in a counter-balanced 
      design. The fat, carbohydrate (CHO) and protein in each diet (as percent energy) 
      were identical at 62:28:10, with 2 day maintenance (1.5 x BMR, MF) beforehand. 
      The ratio of MCT to LCT was 1:2, 1:1 and 2:1 on the low-, (LMCT) medium- (MMCT) 
      and high-MCT (HMCT) diets, respectively. Within each diet every item was of the 
      same composition and offered as a 3 day rotating menu. RESULTS: Energy intakes 
      were significantly lower on the HMCT diet [F (2,240) = 7.52; p < 0.001] giving 
      mean values of 13.50, 13.67, and 12.43 MJ/d on the LMCT, MMCT and HMCT diets, 
      respectively. Food intake followed a parallel trend. By day 14 body weight 
      changes amounted to +0.45, +0.41 and -0.03 kg, respectively. CONCLUSION: These 
      data suggest that substitution of a readily metabolised fat for a less readily 
      metabolised fat, in very high fat diets can limit the excess energy intakes and 
      weight gain that is usually produced by HF, energy-dense diets.
FAU - Stubbs, R J
AU  - Stubbs RJ
AD  - Rowett Research Institute, Bucksburn, Aberdeen.
FAU - Harbron, C G
AU  - Harbron CG
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Obes Relat Metab Disord
JT  - International journal of obesity and related metabolic disorders : journal of the 
      International Association for the Study of Obesity
JID - 9313169
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Dietary Proteins)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adult
MH  - Appetite
MH  - Dietary Carbohydrates/administration & dosage
MH  - Dietary Fats/*administration & dosage
MH  - Dietary Proteins/administration & dosage
MH  - Eating/*drug effects
MH  - *Energy Intake
MH  - Food Preferences
MH  - Humans
MH  - Male
MH  - Taste
MH  - Triglycerides/*administration & dosage/chemistry
MH  - Weight Gain
EDAT- 1996/05/01 00:00
MHDA- 1996/05/01 00:01
CRDT- 1996/05/01 00:00
PHST- 1996/05/01 00:00 [pubmed]
PHST- 1996/05/01 00:01 [medline]
PHST- 1996/05/01 00:00 [entrez]
PST - ppublish
SO  - Int J Obes Relat Metab Disord. 1996 May;20(5):435-44.