PMID- 8696891
OWN - NLM
STAT- MEDLINE
DCOM- 19960903
LR  - 20190920
IS  - 1078-5884 (Print)
IS  - 1078-5884 (Linking)
VI  - 12
IP  - 1
DP  - 1996 Jul
TI  - Biological responses differ considerably between endovascular and conventional 
      aortic aneurysm surgery.
PG  - 18-25
AB  - OBJECTIVES: To determine the inflammatory responses in endovascular abdominal 
      aortic aneurysm (AAA) repair and their relation to clinical findings. DESIGN: 
      Prospective non-randomised study. SETTING: University Hospital, Department of 
      Surgery. PATIENTS AND METHODS: Seven patients treated with an endoluminal 
      procedure (AAA-E) and seven patients undergoing conventional surgery (AAA-C) were 
      included. Inflammatory parameters were assessed by measurements of the cytokines 
      interleukin (IL)-1 beta, IL-6, IL-8 and Tumour Necrosis Factor-alpha (TNF-alpha); 
      analyses of complement proteins C1q, C4, C3, C5a and Terminal Complement 
      Complexes (TCC); haematologic parameters and determination of C-reactive protein 
      (CRP). RESULTS: In six of seven patients in the AAA-E group blood pressure 
      decreases were recorded during introduction of the device. IL-6 and CRP levels 
      were found to be significantly higher in AAA-C patients compared to the AAA-E 
      group. On the other hand, high TNF-alpha levels were recorded in the AAA-E group. 
      Less consumption of the complement proteins C1q, C4 and C3 was observed in AAA-E 
      compared to AAA-C patients. Increased C5a levels were recorded in the AAA-C 
      group, whereas only slight fluctuations were noticed in the AAA-E group. TCC 
      levels were unchanged in both groups. CONCLUSION: Endovascular aortic aneurysm 
      repair induced a significant inflammatory response, mainly involving TNF-alpha 
      and differing from the findings during open AAA repair. These inflammatory 
      responses were probably related to blood pressure decreases during the 
      procedures. On the other hand, conventional repair induced responses related to 
      the more extensive surgical trauma and reperfusion injury.
FAU - Swartbol, P
AU  - Swartbol P
AD  - Department of Surgery, Lund University, Sweden.
FAU - Norgren, L
AU  - Norgren L
FAU - Albrechtsson, U
AU  - Albrechtsson U
FAU - Cwikiel, W
AU  - Cwikiel W
FAU - Jahr, J
AU  - Jahr J
FAU - Jonung, T
AU  - Jonung T
FAU - Parsson, H
AU  - Parsson H
FAU - Ribbe, E
AU  - Ribbe E
FAU - Thorne, J
AU  - Thorne J
FAU - Truedsson, L
AU  - Truedsson L
FAU - Zdanowski, Z
AU  - Zdanowski Z
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Vasc Endovasc Surg
JT  - European journal of vascular and endovascular surgery : the official journal of 
      the European Society for Vascular Surgery
JID - 9512728
RN  - 0 (Complement C3)
RN  - 0 (Complement C4)
RN  - 0 (Complement Membrane Attack Complex)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 80295-33-6 (Complement C1q)
RN  - 80295-54-1 (Complement C5a)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aorta, Abdominal/surgery
MH  - Aortic Aneurysm, Abdominal/*surgery
MH  - Blood Pressure
MH  - Blood Vessel Prosthesis
MH  - C-Reactive Protein/analysis
MH  - Complement C1q/analysis
MH  - Complement C3/analysis
MH  - Complement C4/analysis
MH  - Complement C5a/analysis
MH  - Complement Membrane Attack Complex/analysis
MH  - Cytokines/*analysis
MH  - Humans
MH  - Iliac Artery/surgery
MH  - Interleukin-1/analysis
MH  - Interleukin-6/analysis
MH  - Interleukin-8/analysis
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Tumor Necrosis Factor-alpha/analysis
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - S1078-5884(96)80270-X [pii]
AID - 10.1016/s1078-5884(96)80270-x [doi]
PST - ppublish
SO  - Eur J Vasc Endovasc Surg. 1996 Jul;12(1):18-25. doi: 
      10.1016/s1078-5884(96)80270-x.