PMID- 8697419
OWN - NLM
STAT- MEDLINE
DCOM- 19960830
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 89
IP  - 2
DP  - 1996 Jul 15
TI  - A case of isodicentric 7p as sole abnormality in a patient with acute myeloid 
      leukemia.
PG  - 132-5
AB  - The detection of isochromosomes in the leukemias and in solid tumors has been 
      well described in the literature, the most common being the i(17q), which is 
      found in the blast crisis of CML and terminal stages of acute myeloid leukemia. 
      Reports of isochromosome 7 have, however, been less well represented, 
      particularly isochromosomes of the short arm of chromosome 7, which represent 
      approximately 1% of all reported isochromosomes in neoplasia. We present here a 
      case report of an elderly female patient with AML-M2 who manifested an idic(7p) 
      in the majority of her bone marrow cells. Fluorescence in situ hybridization 
      (FISH) studies with both centromere-7--and chromosome-7--specific DNA probes 
      verified the diagnosis of idic(7p). To the best of our knowledge, this is the 
      first report of this type of leukemia with an acquired idic(7p) as the sole 
      cytogenetic abnormality.
FAU - Beverstock, G C
AU  - Beverstock GC
AD  - Department of Clinical Cytogenetics, University Hospital Leiden, The Netherlands.
FAU - de Meijer, P H
AU  - de Meijer PH
FAU - ten Bokkel Huinink, D
AU  - ten Bokkel Huinink D
FAU - Pruijt, J F
AU  - Pruijt JF
FAU - den Ottolander, G J
AU  - den Ottolander GJ
FAU - Wessels, H W
AU  - Wessels HW
FAU - Mollevanger, P
AU  - Mollevanger P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (DNA Probes)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Bone Marrow/ultrastructure
MH  - *Chromosomes, Human, Pair 7
MH  - DNA Probes
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Isochromosomes
MH  - Leukemia, Myeloid, Acute/*genetics
EDAT- 1996/07/15 00:00
MHDA- 1996/07/15 00:01
CRDT- 1996/07/15 00:00
PHST- 1996/07/15 00:00 [pubmed]
PHST- 1996/07/15 00:01 [medline]
PHST- 1996/07/15 00:00 [entrez]
AID - 0165460895003169 [pii]
AID - 10.1016/0165-4608(95)00316-9 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1996 Jul 15;89(2):132-5. doi: 
      10.1016/0165-4608(95)00316-9.