PMID- 8697424
OWN - NLM
STAT- MEDLINE
DCOM- 19960830
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 89
IP  - 2
DP  - 1996 Jul 15
TI  - A Philadelphia chromosome positive CML patient with a unique translocation 
      studied via GTG-banding and fluorescence in situ hybridization.
PG  - 157-62
AB  - The Philadelphia (Ph) chromosome was the first consistently occurring chromosome 
      abnormality associated with a single cancer type, chronic myelogenous leukemia 
      (CML). This translocation has since been reported with other chromosome 
      abnormalities. The present report describes a case of Ph chromosome positive CML 
      with a unique complex translocation identified using molecular cytogenetics in 
      addition to routine techniques. GTG-banding revealed abnormalities in at least 
      chromosomes 9, 13, 17, and 22. Fluorescence in situ hybridization (FISH) studies 
      were performed as an adjunct to conventional cytogenetic analyses. Using FISH 
      with the Oncor bcr/abl probe, the Ph translocation previously hypothesized was 
      confirmed. Applying FISH with paired painting probes in various combinations, a 
      complex translocation involving chromosomes 9, 13, 15, 17, and 22 was observed. 
      The results of the GTG-banding and FISH studies were compared with each other and 
      correlated with those of the hematological findings. In an extensive search of 
      the medical literature database (Medline, Health, Cancerlit, Ovid, and CINAHL) 
      spanning nearly three decades (1965-1994), we found no previous report of this 
      specific translocation. Therefore, to the best of our knowledge, this is a unique 
      translocation associated with Ph chromosome positive CML.
FAU - Young, C
AU  - Young C
AD  - Department of Pathology, Rhode Island Hospital, Providence 02903, USA.
FAU - Di Benedetto, J Jr
AU  - Di Benedetto J Jr
FAU - Glasser, L
AU  - Glasser L
FAU - Mark, H F
AU  - Mark HF
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Aged
MH  - Bone Marrow/pathology
MH  - *Chromosome Banding
MH  - Chromosomes, Human, Pair 13
MH  - Chromosomes, Human, Pair 15
MH  - Chromosomes, Human, Pair 17
MH  - Chromosomes, Human, Pair 22
MH  - Chromosomes, Human, Pair 9
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics/pathology
MH  - Leukocytes/pathology
MH  - *Translocation, Genetic
EDAT- 1996/07/15 00:00
MHDA- 2001/03/28 10:01
CRDT- 1996/07/15 00:00
PHST- 1996/07/15 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1996/07/15 00:00 [entrez]
AID - 0165-4608(96)00029-5 [pii]
AID - 10.1016/0165-4608(96)00029-5 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1996 Jul 15;89(2):157-62. doi: 
      10.1016/0165-4608(96)00029-5.