PMID- 8697426
OWN - NLM
STAT- MEDLINE
DCOM- 19960830
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 89
IP  - 2
DP  - 1996 Jul 15
TI  - Duplication of chromosome 9 carrying a BCR/ABL chimeric gene in Philadelphia 
      chromosome negative chronic myeloid leukemia.
PG  - 166-9
AB  - We investigated a patient with Philadelphia chromosome (Ph) negative but BCR 
      positive chronic myeloid leukemia (CML) by fluorescence in situ hybridization 
      (FISH). In the chronic phase one chromosome 9 contained a BCR/ABL fusion gene 
      instead of chromosome 22. Although in blast crisis, both chromosomes 9 had 
      BCR/ABL fusion genes. This could be caused by duplication of the rearranged 
      chromosome 9, which may have a significance similar to a double Ph chromosome. 
      This may suggest that the critical event in CML is the formation of a BCR/ABL 
      chimeric gene regardless of its locus in the genome.
FAU - Takahashi, N
AU  - Takahashi N
AD  - Third Department of Internal Medicine, Akita University School of Medicine, 
      Japan.
FAU - Miura, I
AU  - Miura I
FAU - Ohshima, A
AU  - Ohshima A
FAU - Utsumi, S
AU  - Utsumi S
FAU - Nimura, T
AU  - Nimura T
FAU - Hashimoto, K
AU  - Hashimoto K
FAU - Saito, M
AU  - Saito M
FAU - Miura, A B
AU  - Miura AB
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
SB  - IM
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 9
MH  - Fusion Proteins, bcr-abl/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics
MH  - Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative/*genetics
MH  - Male
MH  - Middle Aged
EDAT- 1996/07/15 00:00
MHDA- 1996/07/15 00:01
CRDT- 1996/07/15 00:00
PHST- 1996/07/15 00:00 [pubmed]
PHST- 1996/07/15 00:01 [medline]
PHST- 1996/07/15 00:00 [entrez]
AID - 0165-4608(96)00039-8 [pii]
AID - 10.1016/0165-4608(96)00039-8 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1996 Jul 15;89(2):166-9. doi: 
      10.1016/0165-4608(96)00039-8.