PMID- 8697433
OWN - NLM
STAT- MEDLINE
DCOM- 19960830
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 89
IP  - 2
DP  - 1996 Jul 15
TI  - Monosomy 22 in two ovarian granulosa cell tumors.
PG  - 93-7
AB  - Cytogenetic studies of ovarian sex cord stromal cell tumors, although limited in 
      number, have found trisomy 12 to be a recurring abnormality, especially in 
      fibromas and granulosa cell tumors (GCTs). However, recent fluorescence in situ 
      hybridization (FISH) studies have failed to confirm a high prevalence of trisomy 
      12 in GCTs. We describe the karyotypic findings in one adult and one juvenile 
      GCT. Only the juvenile GCT had an extra, abnormal chromosome 12, but both the 
      adult and juvenile GCT had monosomy 22. In light of these findings and the data 
      in the literature, we suggest that monosomy 22 may be important in the genesis of 
      these relatively rare tumors.
FAU - Lindgren, V
AU  - Lindgren V
AD  - Department of Obstetrics and Gynecology, University of Chicago, Illinois 60637, 
      USA.
FAU - Waggoner, S
AU  - Waggoner S
FAU - Rotmensch, J
AU  - Rotmensch J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Chromosome Aberrations
MH  - Chromosomes, Human, Pair 12
MH  - *Chromosomes, Human, Pair 22
MH  - Female
MH  - Granulosa Cell Tumor/*genetics/pathology
MH  - Humans
MH  - Karyotyping
MH  - *Monosomy
MH  - Ovarian Neoplasms/*genetics/pathology
EDAT- 1996/07/15 00:00
MHDA- 1996/07/15 00:01
CRDT- 1996/07/15 00:00
PHST- 1996/07/15 00:00 [pubmed]
PHST- 1996/07/15 00:01 [medline]
PHST- 1996/07/15 00:00 [entrez]
AID - 0165-4608(96)00077-5 [pii]
AID - 10.1016/0165-4608(96)00077-5 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1996 Jul 15;89(2):93-7. doi: 
      10.1016/0165-4608(96)00077-5.