PMID- 8698290
OWN - NLM
STAT- MEDLINE
DCOM- 19960905
LR  - 20190830
IS  - 0379-0738 (Print)
IS  - 0379-0738 (Linking)
VI  - 79
IP  - 2
DP  - 1996 May 31
TI  - Morphological damage to the central nervous system (CNS) following open heart 
      surgery.
PG  - 103-11
AB  - We investigated 40 patients who had died following open heart surgery between 
      January 1990 and May 1992. Between this time, 703 open heart procedures were 
      carried out at the University Medical School of Debrecen, 2nd Department of 
      Surgery's Cardiac Surgery Unit with a mortality rate of 8.3%. We studied each 
      individual's clinical records, autopsy findings, and histology of defined 
      portions of brain tissue. Clinical information used were: sex, age, clinical 
      stage (according to New York Heart Association (NYHA) classification) at time of 
      surgery, type of procedure performed, and duration of time of extracorporeal 
      circulation. Autopsy records collected and studied focused on the macroscopic and 
      microscopic alterations in the CNS. The most common morphological findings in the 
      CNS for the 40 studies cases were, cerebral edema in all cases, reactive 
      microgliosis and nuclear pyknosis in most cases, and in a minority of the cases 
      focal microscopic hemorrhage or focal microscopic white emolition. Also found 
      were, destructive brain hemorrhage and global cerebral necrosis. Of the 40 cases 
      studied there was only one case in which brain death was diagnosed 
      perioperatively, and which was clinically diagnosed to be caused by global 
      cerebral hypoxia.
FAU - Herczeg, L
AU  - Herczeg L
AD  - University Medical School of Debrecen, Institute of Forensic Medicine, Hungary.
FAU - Gorombey, S
AU  - Gorombey S
FAU - Vaszily, M
AU  - Vaszily M
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
SB  - IM
MH  - Brain Injuries/etiology/mortality/*pathology
MH  - Cardiac Surgical Procedures/*adverse effects/methods
MH  - Extracorporeal Circulation
MH  - Female
MH  - Heart Diseases/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
EDAT- 1996/05/31 00:00
MHDA- 1996/05/31 00:01
CRDT- 1996/05/31 00:00
PHST- 1996/05/31 00:00 [pubmed]
PHST- 1996/05/31 00:01 [medline]
PHST- 1996/05/31 00:00 [entrez]
AID - 0379-0738(96)01896-8 [pii]
AID - 10.1016/0379-0738(96)01896-8 [doi]
PST - ppublish
SO  - Forensic Sci Int. 1996 May 31;79(2):103-11. doi: 10.1016/0379-0738(96)01896-8.