PMID- 8698318
OWN - NLM
STAT- MEDLINE
DCOM- 19960905
LR  - 20190722
IS  - 0046-8177 (Print)
IS  - 0046-8177 (Linking)
VI  - 27
IP  - 7
DP  - 1996 Jul
TI  - Gain and loss of chromosomes 1, 7, 8, 10, 18, and Y in 46 prostate cancers.
PG  - 720-7
AB  - Fluorescence in situ hybridization (FISH) with centromere probes was used to 
      investigate numerical aberrations of chromosomes 1, 7, 8, 10, 18, and Y in 46 
      prostate carcinoma (PC) and 11 benign prostatic hyperplasia (BPH) samples. None 
      of the benign specimens showed any chromosomal aberration. Forty-one of 46 PC 
      specimens showed numerical aberrations of one or more chromosomes. All 
      investigated chromosomes showed numerical aberrations in at least 30% of the 
      specimens, gain being more frequent than loss. Comparison of DNA flow cytometry 
      (FCM) and FISH results showed that not only aneuploid tumors but also most 
      diploid tumors harbored numerical chromosome aberrations. Chromosome 10 was the 
      most frequently gained (65%), and Y the most frequently lost chromosome (14%). 
      Nonmetastatic and metastatic tumors differed significantly (P < .05) in the 
      number of copies for chromosomes 7, 8, and 10, but not for 1, 18, and Y. These 
      results suggest strongly that gains of chromosomes 7, 8, and 10 are involved in 
      PC progression.
FAU - Konig, J J
AU  - Konig JJ
AD  - Department of Urology, Erasmus University, Rotterdam, The Netherlands.
FAU - Teubel, W
AU  - Teubel W
FAU - Romijn, J C
AU  - Romijn JC
FAU - Schroder, F H
AU  - Schroder FH
FAU - Hagemeijer, A
AU  - Hagemeijer A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Aneuploidy
MH  - Chromosomes, Human, Pair 1
MH  - Chromosomes, Human, Pair 10
MH  - Chromosomes, Human, Pair 18
MH  - Chromosomes, Human, Pair 7
MH  - Chromosomes, Human, Pair 8
MH  - DNA, Neoplasm/genetics
MH  - Flow Cytometry
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prostatic Hyperplasia/genetics
MH  - Prostatic Neoplasms/*genetics/pathology
MH  - Y Chromosome
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - S0046-8177(96)90404-9 [pii]
AID - 10.1016/s0046-8177(96)90404-9 [doi]
PST - ppublish
SO  - Hum Pathol. 1996 Jul;27(7):720-7. doi: 10.1016/s0046-8177(96)90404-9.