PMID- 8698345
OWN - NLM
STAT- MEDLINE
DCOM- 19960905
LR  - 20190722
IS  - 0340-6717 (Print)
IS  - 0340-6717 (Linking)
VI  - 98
IP  - 2
DP  - 1996 Aug
TI  - Dual localization of the human gene encoding hnRNP I/PTB protein to chromosomes 
      19p13.3 and 14q23.
PG  - 210-3
AB  - A cDNA probe representative of the human hnRNP I/PTB gene was used to perform 
      fluorescence in situ hybridization (FISH) on metaphases of human chromosomes. A 
      new localization was found on band 19p13.3 in addition to the previously reported 
      localization to band 14q23. Identical results were obtained when FISH analysis 
      was repeated with probes covering different parts of the hnRNP I cDNA clone. This 
      supported the notion that most, if not all, of the sequences of the different 
      parts of this clone are present on both chromosomes. Moreover, Southern blot 
      analysis of DNAs from interspecies somatic hybrids containing chromosomes 19 and 
      14 revealed that the whole hnRNP I cDNA probe generated very similar patterns in 
      each hybrid DNA. These data suggest that two closely related copies of the hnRNP 
      I gene exist in the human genome.
FAU - Della Valle, V
AU  - Della Valle V
AD  - INSERM U-301, Paris, France.
FAU - le Coniat, M
AU  - le Coniat M
FAU - Soulard, M
AU  - Soulard M
FAU - Nguyen, V C
AU  - Nguyen VC
FAU - Berger, R
AU  - Berger R
FAU - Larsen, C J
AU  - Larsen CJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Heterogeneous-Nuclear Ribonucleoproteins)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (Ribonucleoproteins)
RN  - 139076-35-0 (Polypyrimidine Tract-Binding Protein)
SB  - IM
MH  - Blotting, Southern
MH  - Chromosome Banding
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 14/*genetics/ultrastructure
MH  - Chromosomes, Human, Pair 19/*genetics/ultrastructure
MH  - DNA, Complementary
MH  - DNA-Binding Proteins/*genetics
MH  - Heterogeneous-Nuclear Ribonucleoproteins
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Polypyrimidine Tract-Binding Protein
MH  - RNA-Binding Proteins/*genetics
MH  - Ribonucleoproteins/*genetics
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - 10.1007/s004390050193 [doi]
PST - ppublish
SO  - Hum Genet. 1996 Aug;98(2):210-3. doi: 10.1007/s004390050193.