PMID- 8699818
OWN - NLM
STAT- MEDLINE
DCOM- 19960905
LR  - 20061115
IS  - 0023-6764 (Print)
IS  - 0023-6764 (Linking)
VI  - 46
IP  - 1
DP  - 1996 Feb
TI  - Tumor necrosis factor-alpha and interleukin-1 alpha expression in a murine model 
      of allergic bronchopulmonary aspergillosis.
PG  - 42-7
AB  - Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 alpha (IL-1 alpha) are 
      two important proinflammatory cytokines that may be involved in allergic 
      inflammatory processes. We recently developed a murine model of allergic 
      bronchopulmonary aspergillosis characterized by eosinophilic and lymphocyte lung 
      infiltration and increased serum and bronchoalveolar lavage immunoglobulin E 
      concentration. In this study we examined the expression of TNF-alpha and IL-1 
      alpha in the lung tissue sections of C57BL/6 mice that were intranasally 
      challenged with Aspergillus fumigatus antigen or saline on the first 3 days of 
      each week and sacrificed on days 4, 7, 14, and 21. Compared with the control 
      mice, A. fumigatus treated mice had a remarkable increase of TNF-alpha and IL-1 
      alpha expression in the lung on days 4, 14, and 21, with a slight increase on day 
      7. The major types of cells expressing TNF-alpha and IL-1 alpha included alveolar 
      macrophages, endothelial cells, and bronchiolar and alveolar epithelial cells. 
      Consistent with increased expression of TNF-alpha and IL-1 alpha, intercellular 
      adhesion molecule-1 expression also was upregulated in the lung of A. fumigatus 
      treated mice; its time course and cell types were similar to those of TNF-alpha 
      and IL-1 alpha expression. These results suggest that TNF-alpha and IL-1 alpha 
      may be involved in the A. fumigatus induced inflammatory process and that 
      upregulated intercellular adhesion molecule-1 expression may represent one of the 
      roles played by TNF-alpha and IL-1 alpha in this murine model.
FAU - Chu, H W
AU  - Chu HW
AD  - Unite de Recherche, Hopital Laval, Universite Laval, Ste-Foy, Quebec, Canada.
FAU - Wang, J M
AU  - Wang JM
FAU - Boutet, M
AU  - Boutet M
FAU - Laviolette, M
AU  - Laviolette M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Lab Anim Sci
JT  - Laboratory animal science
JID - 1266503
RN  - 0 (Interleukin-1)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Aspergillosis, Allergic Bronchopulmonary/immunology/*pathology
MH  - Bronchoalveolar Lavage Fluid/cytology/immunology
MH  - *Disease Models, Animal
MH  - Female
MH  - Immunoglobulin E/analysis
MH  - Immunohistochemistry
MH  - Intercellular Adhesion Molecule-1/biosynthesis
MH  - Interleukin-1/*biosynthesis
MH  - Leukocyte Count
MH  - Lung/immunology/pathology
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/*biosynthesis
MH  - Up-Regulation/immunology
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
PST - ppublish
SO  - Lab Anim Sci. 1996 Feb;46(1):42-7.