PMID- 8700026
OWN - NLM
STAT- MEDLINE
DCOM- 19960905
LR  - 20170214
IS  - 0094-2405 (Print)
IS  - 0094-2405 (Linking)
VI  - 23
IP  - 1
DP  - 1996 Jan
TI  - Frequency-domain optical mammography: edge effect corrections.
PG  - 149-57
AB  - We have investigated the problem of edge effects in laser-beam transillumination 
      scanning of the human breast. Edge effects arise from tissue thickness 
      variability along the scanned area, and from lateral photon losses through the 
      sides of the breast. Edge effects can be effectively corrected in 
      frequency-domain measurements by employing a two-step procedure: (1) use of the 
      phase information to calculate an effective tissue thickness for each pixel 
      location; (2) application of the knowledge of tissue thickness to calculate an 
      edge-corrected optical image from the ac signal image. The measurements were 
      conducted with a light mammography apparatus (LIMA) designed for feasibility 
      tests in the clinical environment. Operating in the frequency-domain (110 MHz), 
      this instrument performs a transillumination optical scan at two wavelengths (685 
      and 825 nm). We applied the proposed two-step procedure to data from breast 
      phantoms and from human breasts. The processed images provide higher contrast and 
      detectability in optical mammography with respect to raw data breast images.
FAU - Fantini, S
AU  - Fantini S
AD  - Department of Physics, University of Illinois at Urbana-Champaign 61801-3080, 
      USA.
FAU - Franceschini, M A
AU  - Franceschini MA
FAU - Gaida, G
AU  - Gaida G
FAU - Gratton, E
AU  - Gratton E
FAU - Jess, H
AU  - Jess H
FAU - Mantulin, W W
AU  - Mantulin WW
FAU - Moesta, K T
AU  - Moesta KT
FAU - Schlag, P M
AU  - Schlag PM
FAU - Kaschke, M
AU  - Kaschke M
LA  - eng
GR  - CA57032/CA/NCI NIH HHS/United States
GR  - RR03155/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Med Phys
JT  - Medical physics
JID - 0425746
SB  - IM
MH  - Biophysical Phenomena
MH  - Biophysics
MH  - Breast Neoplasms/diagnostic imaging
MH  - Female
MH  - Humans
MH  - Lasers
MH  - Mammography/instrumentation/*methods/statistics & numerical data
MH  - Optics and Photonics/instrumentation
MH  - Phantoms, Imaging
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1118/1.597696 [doi]
PST - ppublish
SO  - Med Phys. 1996 Jan;23(1):149-57. doi: 10.1118/1.597696.