PMID- 8700043
OWN - NLM
STAT- MEDLINE
DCOM- 19960903
LR  - 20190920
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 18
IP  - 1
DP  - 1996 Jan-Feb
TI  - Prenatal haloperidol reduces the number of active midbrain dopamine neurons in 
      rat offspring.
PG  - 49-57
AB  - The dopamine (DA) receptor antagonist, haloperidol (HAL, 1.25 or 5 mg/kg), or 
      vehicle, dimethyl sulfoxide (DMSO), was administered (SC) daily to pregnant 
      Sprague-Dawley dams from gestational day (GD) 8 to GD 20. The average body weight 
      of 2-week-old male offspring was significantly lower in all of the HAL-treated 
      groups relative to controls. In extracellular electrophysiological studies, the 
      male 2-week-old offspring from all HAL treatment groups were found to have 
      significantly reduced average numbers of spontaneously active midbrain dopamine 
      (DA)-containing neurons in both the substantia nigra (A9) and the ventral 
      tegmental area (A10) relative to controls. In DA neurons classified as bursting 
      neurons, HAL exposure (5 mg/kg) caused a significantly increased level of burst 
      activity in A10 but not A9 DA neurons relative to controls. For both the A9 and 
      A10 regions, the proportion of DA neurons classified as bursting or nonbursting 
      was unaffected by HAL treatment. These results suggest that prenatal HAL exposure 
      influences the development of midbrain DA neurons.
FAU - Zhang, J
AU  - Zhang J
AD  - Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health 
      Professions, Wayne State University, Detroit, MI 48202, USA.
FAU - Wang, L
AU  - Wang L
FAU - Pitts, D K
AU  - Pitts DK
LA  - eng
GR  - MH47857/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Dopamine Antagonists)
RN  - J6292F8L3D (Haloperidol)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Cell Count
MH  - Depression, Chemical
MH  - Dopamine/*physiology
MH  - Dopamine Antagonists/*toxicity
MH  - Electrophysiology
MH  - Female
MH  - Haloperidol/*toxicity
MH  - Injections, Subcutaneous
MH  - Male
MH  - Mesencephalon/*cytology/drug effects
MH  - Neurons/*drug effects
MH  - Patch-Clamp Techniques
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 0892036295020233 [pii]
AID - 10.1016/0892-0362(95)02023-3 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 1996 Jan-Feb;18(1):49-57. doi: 
      10.1016/0892-0362(95)02023-3.