PMID- 8703244
OWN - NLM
STAT- MEDLINE
DCOM- 19960912
LR  - 20161021
IS  - 0125-877X (Print)
IS  - 0125-877X (Linking)
VI  - 13
IP  - 2
DP  - 1995 Dec
TI  - Seroprevalence of human herpesvirus 6 and 7 infections in the Thai population.
PG  - 151-7
AB  - Seroprevalence of human herpesvirus 6 (HHV-6) and 7 (HHV-7) was estimated in the 
      Thai population using indirect immunofluorescence assay to determine serum 
      antibodies to HHV-6 and HHV-7. A total of 333 serum samples obtained from 
      umbilical cord blood and venous blood of healthy persons at Siriraj Hospital and 
      Krabi Hospital during 1990-1993 were investigated. Of 73 infants aged 0-1 month, 
      73% and 78% were found tob e positive for HHV-6 and HHV-7 antibodies, 
      respectively. Antibody to HHV-6 was detected in age groups 2-3 months (38%), 4-5 
      months (14%), 6 months (44%), 7-11 months (66%), 1-2 year (84%), 3-4 years (82%), 
      5-9 years (83%), 10-19 years (83%), 20-29 years (80%), 30-39 years (67%), and 
      over 40 years (58%), respectively. This positive rates of HHV-7 antibody in age 
      groups 2-3 months, 4-5 months, 6 months, 7-11 months, 1-2 years, 3-4 years, 5-9 
      years, 10-19 years, 21-29 years, 30-39 years, and over 40 years were 50%, 21%, 
      10%, 37%, 47%, 82%, 75%, 72%, 72%, 67%, and 67%, respectively. At 6 months of age 
      as the starting time of infections, 34% (14/41) and 9% (3/41) of infants had 
      presumed primary infections of HHV-6 and HHV-7, respectively. In the follow-up 
      study, 53% (20/38) of children were infected with HHV-6 prior to HHV-7 and only 
      5% vice versa. Eighty-four percent of children had acquired antibody to HHV-6 by 
      1-2 years old while 82% of children had acquired antibody to HHV-7 by 3-4 years 
      old. These results suggest that HHV-6 and HHV-7 are prevalent viruses in the Thai 
      population. The infections of both viruses begin at 6 months of age. However, 
      infection of HHV-7 in most children begins later. The data also provided evidence 
      that antigenic distinction between HHV-6 and HHV-7 existed with a limited 
      cross-reactivity in an antibody test. The antibody responses to HHV-6 and HHV-7 
      occurred independently.
FAU - Kositanont, U
AU  - Kositanont U
AD  - Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol 
      University, Bangkok, Thailand.
FAU - Wasi, C
AU  - Wasi C
FAU - Ekpatcha, N
AU  - Ekpatcha N
FAU - Poomchart, A
AU  - Poomchart A
FAU - Likanonsakul, S
AU  - Likanonsakul S
FAU - Suphanip, I
AU  - Suphanip I
FAU - Balachandra, K
AU  - Balachandra K
FAU - Yamanishi, K
AU  - Yamanishi K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - Asian Pac J Allergy Immunol
JT  - Asian Pacific journal of allergy and immunology
JID - 8402034
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Antibodies, Viral/*analysis
MH  - Child
MH  - Child, Preschool
MH  - Herpesvirus 6, Human/*immunology
MH  - Herpesvirus 7, Human/*immunology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Seroepidemiologic Studies
MH  - Thailand/epidemiology
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
PST - ppublish
SO  - Asian Pac J Allergy Immunol. 1995 Dec;13(2):151-7.