PMID- 8707741
OWN - NLM
STAT- MEDLINE
DCOM- 19960906
LR  - 20190512
IS  - 0305-7453 (Print)
IS  - 0305-7453 (Linking)
VI  - 37
IP  - 2
DP  - 1996 Feb
TI  - Retention of antibacterial activity and bacterial colonization of 
      antiseptic-bonded central venous catheters.
PG  - 315-22
AB  - We determined how long antiseptic impregnation with silver sulphadiazine and 
      chlorhexidine (SCC) on polyurethane central venous double- or triple-lumen 
      catheters is retained in vivo. A total of 116 antiseptic catheters were tested 
      for antibacterial activity in an in-vitro bioassay after various periods of iv 
      catheterization. Segments from the subcutaneous (sc) and intravenous (iv) 
      portions of the catheters were cultured. The results of test antiseptic catheters 
      were compared with those from 117 noncoated control (c) catheters. Retention of 
      antibacterial activity followed an exponential curve and lasted for up to 520 h 
      after catheter insertion. Significant differences (P = 0.0001) between SSC and C 
      catheters were noticed with regard to the quantitative level of bacterial 
      colonization (SSC-sc 87 +/- 34 vs C-sc 584 +/- 122; SSC-iv 52 +/- 17 vs C-iv 286 
      +/- 57; all values are given as mean cfu +/- S.E.M.), and the frequency of 
      bacterial colonization (SSC-sc 20.7% vs C-sc 38.5%, P = 0.0047; SSC-iv 18.1% vs 
      C-iv 30.8%, P = 0.0361). There was no significant difference between the 
      incidence of catheter-related bacteraemia in the test (n = 0) and control groups 
      (n = 3) (P = 0.2573). Further prospective studies are required to delineate the 
      role of antiseptic catheters in preventing catheter-related infections.
FAU - Bach, A
AU  - Bach A
AD  - Department of Anaesthesiology, University of Heidelberg, Germany.
FAU - Schmidt, H
AU  - Schmidt H
FAU - Bottiger, B
AU  - Bottiger B
FAU - Schreiber, B
AU  - Schreiber B
FAU - Bohrer, H
AU  - Bohrer H
FAU - Motsch, J
AU  - Motsch J
FAU - Martin, E
AU  - Martin E
FAU - Sonntag, H G
AU  - Sonntag HG
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Antimicrob Chemother
JT  - The Journal of antimicrobial chemotherapy
JID - 7513617
RN  - 0 (Disinfectants)
RN  - 0N7609K889 (Sulfadiazine)
RN  - R4KO0DY52L (Chlorhexidine)
SB  - IM
MH  - Bacteremia/etiology
MH  - Bacteria/*drug effects/growth & development
MH  - Catheterization, Central Venous/adverse effects/*instrumentation
MH  - Chlorhexidine/*pharmacology
MH  - Colony Count, Microbial
MH  - Disinfectants/*pharmacology
MH  - Humans
MH  - Sulfadiazine/*pharmacology
MH  - Surface Properties
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
AID - 10.1093/jac/37.2.315 [doi]
PST - ppublish
SO  - J Antimicrob Chemother. 1996 Feb;37(2):315-22. doi: 10.1093/jac/37.2.315.