PMID- 8708958
OWN - NLM
STAT- MEDLINE
DCOM- 19960910
LR  - 20220316
IS  - 0022-3492 (Print)
IS  - 0022-3492 (Linking)
VI  - 67
IP  - 3
DP  - 1996 Mar
TI  - Immunological, genetic, and microbiological study of family members manifesting 
      early-onset periodontitis.
PG  - 254-63
AB  - From the standpoint of host-parasite interactions, family studies help us 
      understand the host defensive factors and the molecular mechanisms involved in 
      the periodontal immune response. In this study, we report the immunological 
      profile of host-defensive functions, human leukocyte antigen (HLA) phenotypes, 
      and the microflora of a mother (rapidly progressive periodontitis), an older son 
      (periodontally healthy), a younger son (localized juvenile periodontitis), and a 
      daughter (localized juvenile periodontitis). We examined the peripheral 
      neutrophil functions, phenotypic and functional analysis of peripheral 
      lymphocytes, serum immunoglobulin G (IgG) antibody titers against 
      periodontopathic bacteria, serological type of HLA class II antigens, and 
      bacterial flora in all periodontal pockets. The results showed that 
      Actinobacillus actinomycetemcomitans was dominant in the pockets of all subjects. 
      The mother and two sons showed a depressed neutrophil chemotaxis to 
      N-formyl-methionyl-leucyl-phenylalanine. All subjects except the older son 
      exhibited low T4/T8 ratios. The mother and daughter had raised levels of IgG 
      titers to Porphyromonas gingivalis. All subjects had HLA phenotypes of DRw52 and 
      DQ1 in common. We found that the family members had similar disorders in certain 
      defensive functions. This family has been a model for our understanding of the 
      host defensive factors in the development of early-onset periodontitis.
FAU - Nakagawa, M
AU  - Nakagawa M
AD  - Department of Periodontology and Endodontology, Okayama University Dental School, 
      Japan.
FAU - Kurihara, H
AU  - Kurihara H
FAU - Nishimura, F
AU  - Nishimura F
FAU - Isoshima, O
AU  - Isoshima O
FAU - Arai, H
AU  - Arai H
FAU - Sawada, K
AU  - Sawada K
FAU - Nagai, A
AU  - Nagai A
FAU - Murayama, Y
AU  - Murayama Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR52 antigen)
RN  - 0 (Immunoglobulin G)
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aggregatibacter actinomycetemcomitans/isolation & purification
MH  - Aggressive Periodontitis/*genetics/immunology/microbiology
MH  - Antibodies, Bacterial/analysis
MH  - CD4-CD8 Ratio
MH  - Chemotaxis, Leukocyte/drug effects/genetics
MH  - Female
MH  - HLA Antigens/analysis/genetics
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DR Serological Subtypes
MH  - Humans
MH  - Immunoglobulin G/blood/immunology
MH  - Male
MH  - N-Formylmethionine Leucyl-Phenylalanine/pharmacology
MH  - Neutrophils/immunology
MH  - Periodontal Pocket/microbiology
MH  - Periodontitis/*genetics/immunology/microbiology
MH  - Phenotype
MH  - Porphyromonas gingivalis/immunology
MH  - T-Lymphocytes/immunology
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
AID - 10.1902/jop.1996.67.3.254 [doi]
PST - ppublish
SO  - J Periodontol. 1996 Mar;67(3):254-63. doi: 10.1902/jop.1996.67.3.254.