PMID- 8709220
OWN - NLM
STAT- MEDLINE
DCOM- 19960910
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 70
IP  - 9
DP  - 1996 Sep
TI  - Determination and analysis of the complete nucleotide sequence of human 
      herpesvirus.
PG  - 5975-89
AB  - Human herpesvirus 7 (HHV-7) is a recently isolated betaherpesvirus that is 
      prevalent in the human population, with primary infection usually occurring in 
      early childhood. HHV-7 is related to human herpesvirus 6 (HHV-6) in terms of both 
      biological and, from limited prior DNA sequence analysis, genetic criteria. 
      However, extensive analysis of the HHV-7 genome has not been reported, and the 
      precise phylogenetic relationship of HHV-7 to the other human betaherpesviruses 
      HHV-6 and human cytomegalovirus has not been determined. Here I report on the 
      determination and analysis of the complete DNA sequence of HHV-7 strain JI. The 
      data establish that the close biological relationship of HHV-6 and HHV-7 is 
      reflected at the genetic level, where there is a very high degree of conservation 
      of genetic content and encoded amino acid sequences. The data also delineate loci 
      of divergence between the HHV-6 and HHV-7 genomes, which occur at the genome 
      terminal in the region of the terminal direct-repeat elements and within limited 
      regions of the unique component. Of potential significance with respect to 
      biological and evolutionary divergence of HHV-6 and HHV-7 are notable structural 
      differences in putative transcriptional regulatory genes specified by the 
      direct-repeat and immediate-early region A loci of these viruses and the absence 
      of an equivalent of the HHV-6 adeno-associated virus type 2 rep gene homolog in 
      HHV-7.
FAU - Nicholas, J
AU  - Nicholas J
AD  - Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA.
LA  - eng
GR  - R29 AID35483/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Glycoproteins)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Child
MH  - Child, Preschool
MH  - DNA Repair
MH  - Genes, Regulator
MH  - *Genome, Viral
MH  - Glycoproteins/biosynthesis
MH  - Herpesvirus 6, Human/genetics
MH  - Herpesvirus 7, Human/*genetics/metabolism
MH  - Humans
MH  - Molecular Sequence Data
MH  - Open Reading Frames
MH  - Polymerase Chain Reaction
MH  - Restriction Mapping
MH  - Sequence Homology, Amino Acid
MH  - Sequence Homology, Nucleic Acid
MH  - Simplexvirus/genetics
MH  - Viral Proteins/biosynthesis/chemistry
PMC - PMC190618
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
PMCR- 1996/09/01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
PHST- 1996/09/01 00:00 [pmc-release]
AID - 10.1128/JVI.70.9.5975-5989.1996 [doi]
PST - ppublish
SO  - J Virol. 1996 Sep;70(9):5975-89. doi: 10.1128/JVI.70.9.5975-5989.1996.