PMID- 8709622
OWN - NLM
STAT- MEDLINE
DCOM- 19960910
LR  - 20190826
IS  - 0145-2126 (Print)
IS  - 0145-2126 (Linking)
VI  - 20
IP  - 6
DP  - 1996 Jun
TI  - Retinoid-regulated expression of BCL-2 and tissue transglutaminase during the 
      differentiation and apoptosis of human myeloid leukemia (HL-60) cells.
PG  - 499-505
AB  - Retinoids induce terminal differentiation and subsequent apoptosis in the human 
      myeloid leukemia (HL-60) cell line. We have previously shown that in HL-60 cells, 
      ligand activation of retinoic acid receptors (RARs) is sufficient to induce 
      differentiation but ligand activation of retinoid X receptors (RXRs) is necessary 
      for the retinoid-induced apoptosis of these cells. In the present studies we have 
      characterized the effect of retinoids on the expression of two apoptosis-linked 
      gene products, BCL-2 and tissue transglutaminase. BCL-2 is a membrane-associated 
      protein whose expression has been linked to the suppression of apoptosis in many 
      cells. Tissue transglutaminase is a protein cross-linking enzyme that accumulates 
      in many cells undergoing apoptotic cell death. Our data suggest that ligand 
      activation of RARs in HL-60 cells results in a global suppression of BCL-2 
      expression whereas ligand activation of both RARs and RXRs triggers the selective 
      accumulation of tissue transglutaminase in the apoptotic HL-60 cells.
FAU - Nagy, L
AU  - Nagy L
AD  - Department of Pharmacology, University of Texas-Houston Medical School 77225, 
      USA.
FAU - Thomazy, V A
AU  - Thomazy VA
FAU - Chandraratna, R A
AU  - Chandraratna RA
FAU - Heyman, R A
AU  - Heyman RA
FAU - Davies, P J
AU  - Davies PJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
RN  - 5688UTC01R (Tretinoin)
RN  - EC 2.3.2.13 (Transglutaminases)
RN  - EH28UP18IF (Isotretinoin)
SB  - IM
MH  - Apoptosis/*drug effects/physiology
MH  - Cell Differentiation/drug effects/physiology
MH  - Down-Regulation/drug effects
MH  - HL-60 Cells/cytology/*drug effects/metabolism
MH  - Humans
MH  - Isotretinoin/*pharmacology
MH  - Proto-Oncogene Proteins/*metabolism
MH  - Proto-Oncogene Proteins c-bcl-2
MH  - Receptors, Retinoic Acid/physiology
MH  - Retinoid X Receptors
MH  - Transcription Factors/physiology
MH  - Transglutaminases/*metabolism
MH  - Tretinoin/*pharmacology
MH  - Up-Regulation/drug effects
EDAT- 1996/06/01 00:00
MHDA- 1996/06/01 00:01
CRDT- 1996/06/01 00:00
PHST- 1996/06/01 00:00 [pubmed]
PHST- 1996/06/01 00:01 [medline]
PHST- 1996/06/01 00:00 [entrez]
AID - 0145-2126(95)00118-2 [pii]
AID - 10.1016/0145-2126(95)00118-2 [doi]
PST - ppublish
SO  - Leuk Res. 1996 Jun;20(6):499-505. doi: 10.1016/0145-2126(95)00118-2.