PMID- 871161
OWN - NLM
STAT- MEDLINE
DCOM- 19770630
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 232
IP  - 5
DP  - 1977 May
TI  - Migrating action potential complex of cholera: a possible prostaglandin-induced 
      response.
PG  - E529-34
AB  - Distal ileal loops of New Zealand white rabbits exposed to cholera toxin 
      demonstrated the presence of a highly organized myoelectric pattern defined as 
      the migrating action potential complex (MAPC). We investigated the mechanism by 
      which cholera enterotoxin stimulates MAPC activity. Certain anti-inflammatory 
      drugs have altered the secretory component of cholera diarrhea. We investigated 
      effects of these anti-inflammatory drugs on the MAPC. Indomethacin, 5.0 mg/kg iv, 
      abolished all MAPC activity. Indomethacin, 1.5 mg/kg iv, or acetylsalicylic acid, 
      150 mg/kg given intragastrically, altered propagation velocity and at times its 
      direction of propagation, but did not abolish the MAPC. An infusion of 
      prostaglandin F2alpha, 2 microng/kg per min intraluminally, induced MAPC activity 
      similar to that of the cholera complex. Indomethacin, 5.0 mg/kg iv, produced no 
      significant changes in number of complexes or propagation velocity. These 
      observations suggested that inhibition of the cholera complex by indomethacin may 
      result from the alteration of prostaglandin synthesis and that prostaglandins may 
      initiate the motility component of cholera diarrhea.
FAU - Mathias, J R
AU  - Mathias JR
FAU - Carlson, G M
AU  - Carlson GM
FAU - Bertiger, G
AU  - Bertiger G
FAU - Martin, J L
AU  - Martin JL
FAU - Cohen, S
AU  - Cohen S
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Bacterial Toxins)
RN  - 0 (Prostaglandins F)
RN  - R16CO5Y76E (Aspirin)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Action Potentials/*drug effects
MH  - Animals
MH  - Aspirin/pharmacology
MH  - Bacterial Toxins/*pharmacology
MH  - Female
MH  - Gastrointestinal Motility/*drug effects
MH  - Ileum/*drug effects
MH  - Indomethacin/pharmacology
MH  - Male
MH  - Muscle Contraction/drug effects
MH  - Muscle, Smooth/drug effects
MH  - Prostaglandins F/*pharmacology
MH  - Rabbits
MH  - *Vibrio cholerae
EDAT- 1977/05/01 00:00
MHDA- 1977/05/01 00:01
CRDT- 1977/05/01 00:00
PHST- 1977/05/01 00:00 [pubmed]
PHST- 1977/05/01 00:01 [medline]
PHST- 1977/05/01 00:00 [entrez]
AID - 10.1152/ajpendo.1977.232.5.E529 [doi]
PST - ppublish
SO  - Am J Physiol. 1977 May;232(5):E529-34. doi: 10.1152/ajpendo.1977.232.5.E529.