PMID- 8712042
OWN - NLM
STAT- MEDLINE
DCOM- 19960909
LR  - 20061115
IS  - 0210-4806 (Print)
IS  - 0210-4806 (Linking)
VI  - 20
IP  - 3
DP  - 1996 Mar
TI  - [PSA and PSAD study in patients with renal dysfunction].
PG  - 255-60
AB  - This study analyzes the changes in serum and urinary PSA values in 28 subjects; 
      13 with creatinine clearance under 75 ml/mn and 15 with creatinine clearance over 
      75 ml/mn. Both groups were compared for prostate size, measured by transrectal 
      ultrasound, prostate weight, serum PSA (SPSA), 24h urine PSA (PSAO), PSA 
      clearance (PSACl), serum creatinine (SCr), creatinine clearance (CrCl), PSA 
      density (PSAD), PSA/creatinine ratio (PSA/Cr) and PSACl/CrCl ratio. Mean values 
      of SPSA and PSAO were 4.5 +/- 0.8 and 222 +/- 29.7 ng/ml respectively, values for 
      SCr, CrCl and PSACl averaging 1.62 +/- 0.2 mgr/dl, 71.6 +/- 6.5 ml/mn and 150.5 
      +/) 32.9 ml/mn. Median prostate size was 32.6 +/- 3.9 cc, with weights of 40.3 
      +/- 4.9 g and mean PSA density (PSAD) 0.13 +/- 0.02. The results of the 
      homogeneity study showed that there are no significant differences between both 
      groups with regard to the variables considered in the study. SPSA values were 
      higher in patients with CrCl < 75; 3.4 vs 5.7, but not significantly. There are 
      no significant differences between PSAO and PSACl values for both groups, even 
      though PSAO levels were higher in patients with CrCl < 75 ml/min (p = 0.1). PSAD 
      values for patients with CrCl > 75 ml/mn were lower than those for patients with 
      CrCl < 75 ml/mn; 0.09 vs 0.17 (p = 0.08). In the entire sample, PSAD levels 
      showed correlation with SPSA and PSA/Cr values; R = 0.63 (P = 0.0003) and r = 0.5 
      (p = 0.009) respectively. Also, they were significantly but inversely correlated 
      with PSACl levels; r = - 0.5 (p = 0.006) and PSACl/CrCl; r = - 0.048 (p = 0.01). 
      No correlation was seen between PSAD values and the following parameters; PSAO (p 
      = 0.7), SCr (p = 0.5) and CrCl (p = 0.27). When the group of patients with CrCl < 
      75 ml/mn is considered, PSAD values are correlated exclusively with PSACl values; 
      r = - 0.69 (p = 0.008) and PSACl/CrCl; r = 0.68 (p = 0.009). Our data appear to 
      indicate that there is a certain relationship between PSAD and the renal function 
      although the physiopathological mechanism responsible for that is unknown. 
      Nevertheless, considering the sample size, more comprehensive studies will be 
      necessary to obtain more convincing results.
FAU - Sanchez de la Muela, P
AU  - Sanchez de la Muela P
AD  - Servicio de Urologia, Hospital Universitario del Aire, Madrid.
FAU - Gonzalez Parra, E
AU  - Gonzalez Parra E
FAU - Blasco, R
AU  - Blasco R
FAU - Vallejo, J
AU  - Vallejo J
FAU - Fanlo, B
AU  - Fanlo B
FAU - Melgarejo, M
AU  - Melgarejo M
FAU - Martin-Laborda, F
AU  - Martin-Laborda F
FAU - Ortiz, A
AU  - Ortiz A
FAU - Labanda, P
AU  - Labanda P
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Estudio de PSA y PSAD en pacientes con disfuncion renal.
PL  - Spain
TA  - Actas Urol Esp
JT  - Actas urologicas espanolas
JID - 7704993
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
SB  - IM
MH  - Aged
MH  - Humans
MH  - Kidney Diseases/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Prostate-Specific Antigen/*analysis
MH  - Prostatic Hyperplasia/*metabolism/pathology
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
PST - ppublish
SO  - Actas Urol Esp. 1996 Mar;20(3):255-60.