PMID- 8712884
OWN - NLM
STAT- MEDLINE
DCOM- 19960910
LR  - 20220419
IS  - 0003-4967 (Print)
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 55
IP  - 3
DP  - 1996 Mar
TI  - High prevalence of arthropathy in HTLV-I carriers on a Japanese island.
PG  - 193-5
AB  - OBJECTIVE: To determine the aetiological relationship between human T cell 
      leukaemia virus type-I (HTLV-I) and arthritis, by performing an epidemiological 
      study of the inhabitants of Tsushima, an island northwest of the main island of 
      Kyushu, Japan, which is an endemic area of HTLV-I. METHODS: A total of 7087 
      people underwent an annual health check, and those with arthropathy had further 
      physical and radiological examinations by rheumatologists. The presence of HTLV-I 
      antibody was determined by the particle agglutinin method, and integration of the 
      proviral DNA in peripheral lymphocytes was confirmed by polymerase chain 
      reaction. RESULTS: HTLV-I was positive in 26.1% of inhabitants; the incidence 
      increased to 37.0% in patients with symptoms of polyarthritis. The prevalence of 
      rheumatoid arthritis (RA) was significantly different between HTLV-I carriers 
      (0.56%) and non-carriers (0.31%). The stage of bone destruction in HTLV-I 
      carriers with articular symptoms was milder than that in RA patients without 
      HTLV-I. The relative risk of HTLV-I infection for polyarthritis was 1.66 (p < 
      0.05). CONCLUSION: This is the first epidemiological report clarifying the 
      association between HTLV-I and polyarthritis. Our results suggest that this viral 
      infection has a relationship to RA.
FAU - Motokawa, S
AU  - Motokawa S
AD  - Department of Orthopaedics, Nagasaki Chuo National Hospital, Japan.
FAU - Hasunuma, T
AU  - Hasunuma T
FAU - Tajima, K
AU  - Tajima K
FAU - Krieg, A M
AU  - Krieg AM
FAU - Ito, S
AU  - Ito S
FAU - Iwasaki, K
AU  - Iwasaki K
FAU - Nishioka, K
AU  - Nishioka K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Antibodies, Viral/*blood
MH  - Arthritis, Rheumatoid/epidemiology/*virology
MH  - Carrier State
MH  - DNA, Viral/analysis
MH  - Female
MH  - HTLV-I Infections/*complications/genetics/immunology
MH  - Humans
MH  - Incidence
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Prevalence
MH  - Risk
PMC - PMC1010128
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
PMCR- 1999/03/01
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
PHST- 1999/03/01 00:00 [pmc-release]
AID - 10.1136/ard.55.3.193 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 1996 Mar;55(3):193-5. doi: 10.1136/ard.55.3.193.