PMID- 8713674
OWN - NLM
STAT- MEDLINE
DCOM- 19970128
LR  - 20190826
IS  - 0305-1870 (Print)
IS  - 0305-1870 (Linking)
VI  - 23
IP  - 5
DP  - 1996 May
TI  - Sodium status, corticosteroid metabolism and blood pressure in normal human 
      subjects and in a patient with abnormal salt appetite.
PG  - 375-8
AB  - 1. A patient with severe hypertension was found to have mildly impaired 11 
      beta-hydroxysteroid dehydrogenase (11 beta-HSD) activity on the basis of urinary 
      steroid metabolite ratios, low plasma aldosterone, angiotensin II and renin 
      levels and marginally low levels of plasma potassium. 2. The patient also had a 
      compulsively high salt intake. 3. We tested the hypothesis that high salt intake 
      may affect 11 beta-HSD activity. 4. High salt intake in normal subjects did not 
      significantly alter either blood pressure or 11 beta-HSD activity. 5. We suggest 
      that the potentially small hypertensive effect of the partial enzyme deficiency 
      in our patient, also reported in patients with essential hypertension, has been 
      markedly amplified by the very high salt intake.
FAU - Ingram, M C
AU  - Ingram MC
AD  - MRC Blood Pressure Unit, Western Infirmary, Glasgow, Scotland.
FAU - Wallace, A M
AU  - Wallace AM
FAU - Collier, A
AU  - Collier A
FAU - Fraser, R
AU  - Fraser R
FAU - Connell, J M
AU  - Connell JM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Australia
TA  - Clin Exp Pharmacol Physiol
JT  - Clinical and experimental pharmacology & physiology
JID - 0425076
RN  - 0 (Adrenal Cortex Hormones)
RN  - 11128-99-7 (Angiotensin II)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - 4964P6T9RB (Aldosterone)
RN  - 9NEZ333N27 (Sodium)
RN  - EC 1.1.- (Hydroxysteroid Dehydrogenases)
RN  - EC 3.4.23.15 (Renin)
SB  - IM
MH  - Adrenal Cortex Hormones/*metabolism
MH  - Adult
MH  - Aldosterone/blood
MH  - Angiotensin II/blood
MH  - Appetite/*physiology
MH  - Female
MH  - Humans
MH  - Hydroxysteroid Dehydrogenases/analysis
MH  - Hypertension/enzymology/*etiology
MH  - Male
MH  - Middle Aged
MH  - Renin/blood
MH  - Sodium/*analysis
MH  - Sodium Chloride/*adverse effects/metabolism
EDAT- 1996/05/01 00:00
MHDA- 1996/05/01 00:01
CRDT- 1996/05/01 00:00
PHST- 1996/05/01 00:00 [pubmed]
PHST- 1996/05/01 00:01 [medline]
PHST- 1996/05/01 00:00 [entrez]
AID - 10.1111/j.1440-1681.1996.tb02744.x [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol. 1996 May;23(5):375-8. doi: 
      10.1111/j.1440-1681.1996.tb02744.x.