PMID- 8717371
OWN - NLM
STAT- MEDLINE
DCOM- 19961011
LR  - 20190826
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 35
IP  - 1-2
DP  - 1996 Jan
TI  - Heat shock factor-1 mediates the transcriptional activation of Alzheimer's 
      beta-amyloid precursor protein gene in response to stress.
PG  - 325-8
AB  - Stress may be involved in the pathogenesis of Alzheimer's disease. There is a 
      heat shock element located at position -317 bp on the beta-amyloid precursor 
      protein (beta-APP) gene promoter. Recently we demonstrated [4] that stress, in 
      the form of heat shock, ethanol and sodium arsenite treatment, transcriptionally 
      activates the beta-APP gene. In this report we demonstrate that the nuclear 
      factor that mediates this activation is heat shock factor-1.
FAU - Dewji, N N
AU  - Dewji NN
AD  - Department of Medicine, University of California at San Diego, La Jolla 92093, 
      USA.
FAU - Do, C
AU  - Do C
LA  - eng
GR  - NS27580/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Arsenites)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Heat Shock Transcription Factors)
RN  - 0 (Oligodeoxyribonucleotides)
RN  - 0 (Sodium Compounds)
RN  - 0 (Transcription Factors)
RN  - 3K9958V90M (Ethanol)
RN  - 48OVY2OC72 (sodium arsenite)
SB  - IM
MH  - Amyloid beta-Protein Precursor/*biosynthesis/genetics
MH  - Arsenites/pharmacology
MH  - Base Sequence
MH  - Cell Line
MH  - Consensus Sequence
MH  - DNA-Binding Proteins/*metabolism
MH  - Ethanol/pharmacology
MH  - Heat Shock Transcription Factors
MH  - Hot Temperature
MH  - Humans
MH  - Molecular Sequence Data
MH  - Oligodeoxyribonucleotides
MH  - *Promoter Regions, Genetic
MH  - Sodium Compounds/pharmacology
MH  - Stress, Physiological
MH  - Transcription Factors
MH  - *Transcriptional Activation/drug effects
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 0169-328X(95)00214-D [pii]
AID - 10.1016/0169-328x(95)00214-d [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 1996 Jan;35(1-2):325-8. doi: 
      10.1016/0169-328x(95)00214-d.