PMID- 8720717
OWN - NLM
STAT- MEDLINE
DCOM- 19961003
LR  - 20200324
IS  - 0721-832X (Print)
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 234
IP  - 3
DP  - 1996 Mar
TI  - Susceptibility of human retinal pigment epithelial cells to different viruses.
PG  - 177-85
AB  - BACKGROUND: Different viruses have been reported to be involved in retinal 
      diseases in animal systems. In humans, herpes simplex virus and cytomegalovirus 
      have been found to cause retinal disease. Most of the studied viruses are 
      neurotropic. In this study, the in vitro susceptibility of human retinal pigment 
      epithelial cells (RPEC) to representative members of different groups of human 
      pathogenic viruses was investigated. METHODS: Early cultures of RPE C - after two 
      or three passages - were infected with the following viruses: herpes simplex 
      virus (HSV) type 1, human herpesvirus 6 (HHV-6), Epstein-Barr virus (EBV), 
      cytomegalovirus (CMV), adenovirus types 1 and 7, measles virus, parainfluenza 
      virus and coxsackie virus B3. RESULTS: Cultures of RPE C could be infected with 
      neurotropic viruses like HSV or measles virus as well as with typical respiratory 
      viruses like parainfluenza or adenoviruses. Coxsackievirus, an enterovirus, 
      replicated as well as human CMV, whereas EBV and HHV-6, two lymphotropic viruses, 
      failed to infect RPE. CONCLUSION: These findings suggest that a variety of 
      viruses, including those causing rather common illnesses, might be capable of 
      inducing retinal lesions under certain circumstances due to haematogenous spread 
      during the course of viraemia.
FAU - Huemer, H P
AU  - Huemer HP
AD  - Institute for Hygiene, University of Innsbruck, Austria.
FAU - Larcher, C
AU  - Larcher C
FAU - Kirchebner, W
AU  - Kirchebner W
FAU - Klingenschmid, J
AU  - Klingenschmid J
FAU - Gottinger, W
AU  - Gottinger W
FAU - Irschick, E U
AU  - Irschick EU
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigens, Viral)
SB  - IM
MH  - Antibodies, Monoclonal/immunology
MH  - Antibodies, Viral/immunology
MH  - Antigens, Viral/analysis
MH  - Cells, Cultured
MH  - Cytopathogenic Effect, Viral
MH  - DNA Viruses/*growth & development/immunology
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Pigment Epithelium of Eye/cytology/*virology
PMC - PMC7088335
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
PMCR- 2020/03/23
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
PHST- 2020/03/23 00:00 [pmc-release]
AID - BF00462030 [pii]
AID - 10.1007/BF00462030 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 1996 Mar;234(3):177-85. doi: 
      10.1007/BF00462030.