PMID- 8721653
OWN - NLM
STAT- MEDLINE
DCOM- 19960923
LR  - 20190626
IS  - 0002-8703 (Print)
IS  - 0002-8703 (Linking)
VI  - 131
IP  - 4
DP  - 1996 Apr
TI  - Relation of Doppler transmitral flow patterns to functional status in congestive 
      heart failure.
PG  - 766-71
AB  - We analyzed the relation of Doppler transmitral flow patterns and New York Heart 
      Association (NYHA) classification in 60 consecutive patients with heart failure 
      (44 men and 16 women; mean age 58 +/- 13 years) with left ventricular ejection 
      fraction of < 40 percent. Of the study population, 40 patients with mild to 
      moderate heart failure underwent symptom-limited exercise testing. The relation 
      of transmitral flow pattern and exercise tolerance was also analyzed. Doppler 
      echocardiography was performed in all patients. The patients were subdivided into 
      nonrestrictive and restrictive groups according to the pattern. The univariate 
      analysis showed a relation for left ventricular ejection fraction (p = 0.01 by 
      analysis of variance testing) and transmitral flow pattern (p = 0.0003 by 
      chi-squared test) with NYHA classification. When the multivariate regression 
      analysis was performed, only the restrictive pattern by Doppler emerged as an 
      independent determinant of the advanced NYHA class (p = 0.005). In mild to 
      moderate congestive heart failure, patients with nonrestrictive pattern exercised 
      significantly longer than those with the restrictive pattern by an average of 133 
      seconds (p = 0.003) despite comparable reductions in ejection fraction. Thus the 
      restrictive transmitral flow pattern by Doppler is a noninvasive marker for 
      severe symptoms and diminished exercise tolerance in heart failure patients.
FAU - Xie, G Y
AU  - Xie GY
AD  - Division of Cardiovascular Medicine, University of Kentucky and Veterans 
      Administration Medical Centers, Lexington, KY 40536-0084, USA.
FAU - Berk, M R
AU  - Berk MR
FAU - Smith, M D
AU  - Smith MD
FAU - DeMaria, A N
AU  - DeMaria AN
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
SB  - IM
MH  - Aged
MH  - Analysis of Variance
MH  - Chi-Square Distribution
MH  - Diastole
MH  - Echocardiography, Doppler
MH  - Exercise Test
MH  - Female
MH  - Heart Failure/*diagnostic imaging/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve/*diagnostic imaging/*physiopathology
MH  - Severity of Illness Index
MH  - *Ventricular Function, Left
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
AID - S0002-8703(96)90285-9 [pii]
AID - 10.1016/s0002-8703(96)90285-9 [doi]
PST - ppublish
SO  - Am Heart J. 1996 Apr;131(4):766-71. doi: 10.1016/s0002-8703(96)90285-9.