PMID- 8722074
OWN - NLM
STAT- MEDLINE
DCOM- 19961011
LR  - 20211203
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 18
IP  - 11
DP  - 1995 Nov
TI  - Transcomplementation of HLA DQA1-DQB1 in DR3/DR4 and DR3/DR9 heterozygotes and 
      IDDM in Taiwanese families.
PG  - 1483-6
AB  - OBJECTIVE: To study the human leukocyte antigen (HLA)-DQ heterodimers in the 
      susceptible DR haplotypes for patients with insulin-dependent diabetes mellitus 
      (IDDM) in Taiwan. RESEARCH DESIGN AND METHODS: Extended class II HLA haplotypes 
      were studied in 57 unrelated IDDM patients, 31 simplex IDDM families, and 105 
      unrelated control subjects recruited from the same area in Taiwan. Class II HLA 
      genotyping was based on PCR-SSO DNA typing techniques. Extended class II HLA 
      haplotypes were deduced unequivocally by the Taiwanese pedigree studies. RESULTS: 
      DR3/DR3, DR3/DR4, and DR3/DR9 genotypes were strongly associated with IDDM 
      susceptibility in this population. In addition to the reported DR3/DR4 in 
      Caucasians, the heterozygotic effect of DR3/DR9 for IDDM was remarkable in the 
      Taiwanese population. Extended HLA haplotypes studies revealed that 
      DRB1*0301/DQA1*0501/DQB1*0201, DRB1*0405/DQA1*0301/DQB1*0302, and 
      DRB1*0405/DQA1*0301/DQB1*0401 were the susceptible haplotypes in this population. 
      There were several hypothetical ways to produce susceptible HLA-DQ heterodimers 
      to explain the susceptibility carried by DR3/DR4 and DR3/DR9 genotypes. Among all 
      DR4 subtypes, only DRB1*0405 was associated with the increased risk of IDDM. 
      CONCLUSIONS: These data strongly suggest that the HLA-DR-associated IDDM 
      susceptibility is most likely explained by the formation of the susceptible DQ 
      heterodimers encoded by the DQA1/DQB1 either in cis or in trans.
FAU - Chuang, L M
AU  - Chuang LM
AD  - Department of Internal Medicine, National Taiwan University, Taipei, Taiwan.
FAU - Wu, H P
AU  - Wu HP
FAU - Tsai, W Y
AU  - Tsai WY
FAU - Lin, B J
AU  - Lin BJ
FAU - Tai, T Y
AU  - Tai TY
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR3 Antigen)
RN  - 0 (HLA-DR4 Antigen)
RN  - 0 (HLA-DR9 antigen)
SB  - IM
MH  - Confidence Intervals
MH  - Diabetes Mellitus, Type 1/*genetics/*immunology
MH  - Disease Susceptibility
MH  - Ethnicity
MH  - Family
MH  - Genetic Complementation Test
MH  - Genotype
MH  - HLA-DQ Antigens/blood/*genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/blood/*genetics
MH  - HLA-DR Serological Subtypes
MH  - HLA-DR3 Antigen/blood/*genetics
MH  - HLA-DR4 Antigen/blood/*genetics
MH  - Haplotypes
MH  - Heterozygote
MH  - Humans
MH  - Polymerase Chain Reaction
MH  - Racial Groups
MH  - Reference Values
MH  - Taiwan
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
AID - 10.2337/diacare.18.11.1483 [doi]
PST - ppublish
SO  - Diabetes Care. 1995 Nov;18(11):1483-6. doi: 10.2337/diacare.18.11.1483.