PMID- 8724857
OWN - NLM
STAT- MEDLINE
DCOM- 19960917
LR  - 20180215
IS  - 0300-5526 (Print)
IS  - 0300-5526 (Linking)
VI  - 38
IP  - 5
DP  - 1995
TI  - Antibody responses to Epstein-Barr virus, human herpesvirus 6 and human 
      herpesvirus 7 in patients with chronic fatigue syndrome.
PG  - 269-73
AB  - To test for an association between chronic fatigue syndrome (CFS) and infections 
      with Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6) and human herpesvirus 
      7 (HHV-7), antibodies to these viruses were tested in the serum from three groups 
      of individuals: (1) 10 CFS patients with chronic fatigue beginning with a 
      clinical pattern of acute infectious mononucleosis [IM; true chronic IM (CIM)]; 
      (2) 10 CFS patients whose illness did not start with acute IM (non-CIM), and (3) 
      healthy controls. High EBV antibody titers were demonstrated in most patients. 
      Antibodies to ZEBRA, a product of the immediate early EBV gene BZLF1, were 
      detected in the serum of CFS patients at a higher frequency than in healthy 
      controls. Antibody titers to HHV-6 and HHV-7 were also higher in the patients 
      with CFS than in the controls. These results are consistent with the view that 
      CFS patients may have reactivations of EBV, HHV-6 and HHV-7.
FAU - Sairenji, T
AU  - Sairenji T
AD  - Department of Pathology, National Institute of Health, Tokyo, Japan.
FAU - Yamanishi, K
AU  - Yamanishi K
FAU - Tachibana, Y
AU  - Tachibana Y
FAU - Bertoni, G
AU  - Bertoni G
FAU - Kurata, T
AU  - Kurata T
LA  - eng
GR  - AI-23061/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Intervirology
JT  - Intervirology
JID - 0364265
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (BZLF1 protein, Herpesvirus 4, Human)
RN  - 0 (CD69 antigen)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Trans-Activators)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Adult
MH  - Antibodies, Viral/*analysis
MH  - *Antigens, CD
MH  - Antigens, Differentiation, T-Lymphocyte/immunology
MH  - DNA-Binding Proteins/immunology
MH  - Fatigue Syndrome, Chronic/immunology/*virology
MH  - Herpesvirus 4, Human/immunology/*isolation & purification
MH  - Herpesvirus 6, Human/immunology/*isolation & purification
MH  - Herpesvirus 7, Human/immunology/*isolation & purification
MH  - Humans
MH  - Lectins, C-Type
MH  - Trans-Activators/immunology
MH  - Viral Proteins/immunology
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1159/000150450 [doi]
PST - ppublish
SO  - Intervirology. 1995;38(5):269-73. doi: 10.1159/000150450.