PMID- 8725477
OWN - NLM
STAT- MEDLINE
DCOM- 19961001
LR  - 20131121
IS  - 0095-6562 (Print)
IS  - 0095-6562 (Linking)
VI  - 67
IP  - 5
DP  - 1996 May
TI  - Effect of low altitude on glycolytic key enzymes in red blood cells.
PG  - 478-9
AB  - METHOD: The ATP level and the activities of hexokinase (HK), 
      phosphofructokinase-1 (PFK-1) and pyruvate kinase (PK) in red blood cells (RBC) 
      were measured in 50 school students 6-12 yr of age in the Jordan Valley (JV) 
      which is the lowest region below sea level in the world (low altitude: 390 m 
      below sea level, hyperoxic and with an average daily value of 796 mmHg barometric 
      pressure) and in 50 school students of the same age group in Irbid region (normal 
      altitude: 600 m above sea level and with an average daily value of 600 mmHg 
      barometric pressure). The same parameters were measured also in 40 school 
      students at sea level. RESULTS: A significant decrease in HK and PFK-1 activities 
      and an increase in ATP level in the low altitude region, while no significant 
      change in PK activity in JV-group when compared to Irbid and to the sea level 
      control groups. Possible explanations will be discussed to interpret these 
      observations.
FAU - Bashir, N A
AU  - Bashir NA
AD  - Department of Physiology and Biochemistry, Faculty of Medicine, Jordan University 
      of Science and Technology, Irbid, Jordan.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Aviat Space Environ Med
JT  - Aviation, space, and environmental medicine
JID - 7501714
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 2.7.1.11 (Phosphofructokinase-1)
RN  - EC 2.7.1.40 (Pyruvate Kinase)
SB  - IM
MH  - Adenosine Triphosphate/metabolism
MH  - *Altitude
MH  - Child
MH  - Erythrocytes/*enzymology
MH  - *Glycolysis
MH  - Hexokinase/metabolism
MH  - Humans
MH  - Male
MH  - Phosphofructokinase-1/metabolism
MH  - Pyruvate Kinase/metabolism
EDAT- 1996/05/01 00:00
MHDA- 1996/05/01 00:01
CRDT- 1996/05/01 00:00
PHST- 1996/05/01 00:00 [pubmed]
PHST- 1996/05/01 00:01 [medline]
PHST- 1996/05/01 00:00 [entrez]
PST - ppublish
SO  - Aviat Space Environ Med. 1996 May;67(5):478-9.