PMID- 8725625
OWN - NLM
STAT- MEDLINE
DCOM- 19961121
LR  - 20190830
IS  - 0160-564X (Print)
IS  - 0160-564X (Linking)
VI  - 20
IP  - 5
DP  - 1996 May
TI  - Experimental glomerulosclerosis: Defektheilung of the kidney.
PG  - 445-50
AB  - Research in the role of cytokines in experimental glomerulonephritis has 
      increased our understanding of the mechanisms that may be involved in the 
      development of progressive renal disease. Glomerulosclerosis, the final common 
      pathway in a variety of underlying kidney diseases, is characterized by increased 
      extracellular matrix formation and cell proliferation. Transforming growth 
      factor-beta (TGF-beta) and monocyte chemoattractant protein-1 (MCP-1) have been 
      identified in animal models as mediators in the processes that follow renal 
      injury. There is evidence of similar events occurring in other fibrotic 
      disorders, suggesting that there is a common generic pathway of fibrosis. This 
      review summarizes our knowledge of TGF-beta and MCP-1 in experimental kidney 
      disease and compares these results with mechanisms described in other organs. We 
      propose that glomerulosclerosis represents Defektheilung (healing by secondary 
      intention) of the kidney after various injuries. The growing knowledge of the 
      mechanisms involved will help advance future therapeutic interventions by 
      directing the healing process toward primary healing.
FAU - Schiller, B
AU  - Schiller B
AD  - Department of Medicine, Evanston Hospital, Northwestern University, Illinois 
      60201, USA.
FAU - Moran, J
AU  - Moran J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Artif Organs
JT  - Artificial organs
JID - 7802778
RN  - 0 (Chemokine CCL2)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/metabolism
MH  - Disease Models, Animal
MH  - Fibrosis
MH  - Glomerulosclerosis, Focal Segmental/*etiology/pathology
MH  - Kidney/*injuries/pathology
MH  - Kidney Glomerulus/*pathology
MH  - Transforming Growth Factor beta/metabolism
MH  - Wound Healing/drug effects
RF  - 50
EDAT- 1996/05/01 00:00
MHDA- 1996/05/01 00:01
CRDT- 1996/05/01 00:00
PHST- 1996/05/01 00:00 [pubmed]
PHST- 1996/05/01 00:01 [medline]
PHST- 1996/05/01 00:00 [entrez]
AID - 10.1111/j.1525-1594.1996.tb04530.x [doi]
PST - ppublish
SO  - Artif Organs. 1996 May;20(5):445-50. doi: 10.1111/j.1525-1594.1996.tb04530.x.