PMID- 872844
OWN - NLM
STAT- MEDLINE
DCOM- 19770812
LR  - 20180214
IS  - 0014-3022 (Print)
IS  - 0014-3022 (Linking)
VI  - 15
IP  - 4
DP  - 1977
TI  - The transfer of IgG from serum to CSF, evaluated by means of a naturally 
      occurring antibody.
PG  - 231-6
AB  - Titres in CSF of natural IgG antibodies (AB) to rabbit erythrocytes (RRBC) 
      correlated well with titres in serum in normal individuals, indication a passive 
      transfer of the Ab. The ratio of CSF Ab to serum Ab mostly found was 1:400. The 
      ratios of total IgG were slightly lower than the ratios of Ab to RRBC in normal 
      individuals and in the majority of the diseases, except in multiple sclerosis and 
      in subacute sclerosing panencephalitis (SSPE) where the ratios of total IgG were 
      markedly elevated, indicating production of IgG in the central nervous system. In 
      SSPE the ratio of measles Ab was even more elevated, suggesting that these 
      antibodies contribute to the local IgG production. The ratios of Ab to RRBC in 
      the two diseases were not elevated, or only slightly elevated. In normal and 
      pathological CSF and in the Ab to RRBC all subclasses of IgG were found. In 
      conclusion, the Ab to RRBC are considered convenient markers of serum IgG in the 
      CSF.
FAU - Fossan, G O
AU  - Fossan GO
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Eur Neurol
JT  - European neurology
JID - 0150760
RN  - 0 (Antibodies)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Antibodies/analysis
MH  - *Blood-Brain Barrier
MH  - Humans
MH  - Immunoglobulin G/biosynthesis/*cerebrospinal fluid
MH  - Nervous System Diseases/cerebrospinal fluid/immunology
EDAT- 1977/01/01 00:00
MHDA- 1977/01/01 00:01
CRDT- 1977/01/01 00:00
PHST- 1977/01/01 00:00 [pubmed]
PHST- 1977/01/01 00:01 [medline]
PHST- 1977/01/01 00:00 [entrez]
AID - 10.1159/000114838 [doi]
PST - ppublish
SO  - Eur Neurol. 1977;15(4):231-6. doi: 10.1159/000114838.