PMID- 8731459
OWN - NLM
STAT- MEDLINE
DCOM- 19961024
LR  - 20071114
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 39
IP  - 8
DP  - 1996 Apr 15
TI  - Premature disinhibition of P3 generation in schizophrenia.
PG  - 714-9
AB  - P300 (P3) is a long-latency cognitive event-related potential (ERP) elicited by 
      relevant target stimuli. P3 was recorded from 11 schizophrenics and 13 normal 
      controls during a cued visual continuous performance task (CPT-AX). Cue-target 
      sequences were presented at short and long interstimulus intervals (ISIs), in 
      order to investigate working memory in schizophrenia. There was no significant 
      between-group difference in P3 amplitude to validly or invalidly cued targets at 
      short ISI. In contrast, P3 amplitude to invalidly cued targets at long ISI was 
      significantly greater in schizophrenics than in controls, suggesting decreased 
      ability to encode or maintain inhibitory representations of stimulus context. P3 
      amplitude is typically reduced in schizophrenic subjects in the auditory 
      modality, and normal or reduced in the visual modality. This study, which 
      demonstrates a paradoxical P3 increase to targets at long ISI, suggests that P3 
      impairment in schizophrenia cannot be attributed solely to structural deficits 
      within P3-generator regions.
FAU - Shelley, A M
AU  - Shelley AM
AD  - Department of Psychiatry, Albert Einstein College of Medicine@Bronx Psychiatric 
      Center, NY 10461, USA.
FAU - Grochowski, S
AU  - Grochowski S
FAU - Lieberman, J A
AU  - Lieberman JA
FAU - Javitt, D C
AU  - Javitt DC
LA  - eng
GR  - R01 MH41646/MH/NIMH NIH HHS/United States
GR  - R03 MH53345/MH/NIMH NIH HHS/United States
GR  - R29 MH49334/MH/NIMH NIH HHS/United States
GR  - etc.
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
SB  - IM
MH  - Adult
MH  - Cognition/physiology
MH  - Cues
MH  - Electroencephalography
MH  - Electrooculography
MH  - Event-Related Potentials, P300/*physiology
MH  - Humans
MH  - Memory/physiology
MH  - Middle Aged
MH  - Psychomotor Performance/physiology
MH  - Schizophrenia/*physiopathology
EDAT- 1996/04/15 00:00
MHDA- 1996/04/15 00:01
CRDT- 1996/04/15 00:00
PHST- 1996/04/15 00:00 [pubmed]
PHST- 1996/04/15 00:01 [medline]
PHST- 1996/04/15 00:00 [entrez]
AID - 0006-3223(95)00222-7 [pii]
AID - 10.1016/0006-3223(95)00222-7 [doi]
PST - ppublish
SO  - Biol Psychiatry. 1996 Apr 15;39(8):714-9. doi: 10.1016/0006-3223(95)00222-7.