PMID- 8731827
OWN - NLM
STAT- MEDLINE
DCOM- 19961203
LR  - 20140226
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 34
IP  - 10
DP  - 1995 Oct
TI  - [A study on protein metabolism in nephrotic patients treated with Chinese herbs].
PG  - 670-2
AB  - It was found in our previous studies that two Chinese herbs Astragali and 
      Angelica (A&A) together with high protein diet could ameliorate the lowering of 
      serum albumin level and increase the synthesis rate of protein as shown by 
      15N-glicine tracer priming protein turnover study in nephrotic rats. Further 
      experiment was designed to investigate the role of A&A and high protein intake in 
      protein dynamic study and nitrogen balance in nephrotic patients. The level of 
      serum total protein (STP), serum albumin (SA), urinary protein loss (UP), serum 
      cholesterol (Cho) and index number of protein turnover and nitrogen balance in 7 
      patients were measured before and after treatment of 30 days with A&A. The 
      results showed that after treatment the patients had significantly increased STA 
      and SA (44.3 +/- 5.60 vs 49.7 +/- 6.80 P < 0.01; 22.6 +/- 0.42 vs. 29.4 +/- 7.40 
      P < 0.05), decreased UP and Cho (6.54 +/- 1.83 vs 4.63 +/- 1.33 P < 0.05; 9.69 
      +/- 2.31 vs. 7.82 +/- 1.95 P < 0.05) and increased net rates of total protein 
      synthesis (1.06 +/- 0.03 vs 1.27 +/- 0.12 P < 0.05). It is concluded that A&A 
      together with high protein intake could improve the disorder of protein 
      metabolism and increase the level of serum protein by improving the net rate of 
      protein synthesis in nephrotic patients.
FAU - Li, L
AU  - Li L
AD  - Nephrology Institute, Beijing Medical University.
FAU - Yu, H
AU  - Yu H
FAU - Pan, J
AU  - Pan J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
RN  - 0 (Albumins)
RN  - 0 (Blood Proteins)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - N762921K75 (Nitrogen)
SB  - IM
MH  - Adult
MH  - Albumins/metabolism
MH  - Animals
MH  - Blood Proteins/biosynthesis/*metabolism
MH  - Cholesterol/blood
MH  - Drugs, Chinese Herbal/pharmacology/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nephrotic Syndrome/drug therapy/*metabolism
MH  - Nitrogen/metabolism
MH  - Rats
EDAT- 1995/10/01 00:00
MHDA- 1995/10/01 00:01
CRDT- 1995/10/01 00:00
PHST- 1995/10/01 00:00 [pubmed]
PHST- 1995/10/01 00:01 [medline]
PHST- 1995/10/01 00:00 [entrez]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 1995 Oct;34(10):670-2.