PMID- 8732637
OWN - NLM
STAT- MEDLINE
DCOM- 19961118
LR  - 20190920
IS  - 0785-3890 (Print)
IS  - 0785-3890 (Linking)
VI  - 28
IP  - 2
DP  - 1996 Apr
TI  - High-resolution fluorescence in situ hybridization: a new approach in genome 
      mapping.
PG  - 101-6
AB  - Mapping of the human genome has been a global effort utilizing both genetic and 
      physical mapping techniques. One approach which has greatly facilitated the 
      physical mapping of the human genome is fluorescence in situ hybridization 
      (FISH). Although FISH is by now a well-established technology, new recently 
      developed modifications have enabled an easier use and higher resolution. The 
      high-resolution FISH techniques have given a special impact in positional 
      cloning: searching the functional gene from a chromosomal area where the gene has 
      been genetically localized. New high-resolution FISH techniques include 
      hybridization of probes to free chromatin, DNA fibres or mechanically stretched 
      chromosomes. These targets have widened the resolution of FISH to detect 
      distances from the traditional cytogenetic resolution level down to a resolution 
      of a few kilobases. They also have significantly speeded up high-resolution 
      physical mapping and thus made the search of new disease genes easier.
FAU - Palotie, A
AU  - Palotie A
AD  - Laboratory Department of Helsinki University Central Hospital, Finland.
FAU - Heiskanen, M
AU  - Heiskanen M
FAU - Laan, M
AU  - Laan M
FAU - Horelli-Kuitunen, N
AU  - Horelli-Kuitunen N
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Ann Med
JT  - Annals of medicine
JID - 8906388
SB  - IM
MH  - Chromosome Mapping/*methods
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Sensitivity and Specificity
RF  - 54
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
AID - 10.3109/07853899609092933 [doi]
PST - ppublish
SO  - Ann Med. 1996 Apr;28(2):101-6. doi: 10.3109/07853899609092933.