PMID- 8732869
OWN - NLM
STAT- MEDLINE
DCOM- 19961024
LR  - 20061115
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 49
IP  - 1
DP  - 1996 May
TI  - Human herpesvirus 6 induces IL-8 gene expression in human hepatoma cell line, Hep 
      G2.
PG  - 34-40
AB  - The infectivity of human herpesvirus 6 (HHV-6) in a human hepatoma cell line, Hep 
      G2 cells, and the effect of HHV-6 on production of inflammatory cytokines in 
      these cells were examined to analyze pathogenesis of HHV-6 in the liver. We 
      demonstrated that Hep G2 cells were susceptible to infection with HHV-6, and 
      produced infectious virus. Moreover, infection of Hep G2 cells by HHV-6 induced 
      the expression of IL-8 mRNA, but not IL-1 beta. The effect on induction of IL-8 
      gene expression was observed only in Hep G2 cells infected with infectious virus, 
      whereas both heat-inactivated HHV-6 and UV-irradiated HHV-6 did not change the 
      IL-8 mRNA level in these cells. These data suggest that HHV-6 may induce the 
      cytokine-mediated inflammatory response by infecting liver cells, which could 
      result in liver dysfunction in vivo.
FAU - Inagi, R
AU  - Inagi R
AD  - Department of Microbiology, Osaka University Medical School, Japan.
FAU - Guntapong, R
AU  - Guntapong R
FAU - Nakao, M
AU  - Nakao M
FAU - Ishino, Y
AU  - Ishino Y
FAU - Kawanishi, K
AU  - Kawanishi K
FAU - Isegawa, Y
AU  - Isegawa Y
FAU - Yamanishi, K
AU  - Yamanishi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Antigens, Viral)
RN  - 0 (DNA Primers)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-8)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Antigens, Viral/analysis
MH  - Base Sequence
MH  - Carcinoma, Hepatocellular
MH  - DNA Primers
MH  - Gene Expression Regulation
MH  - Heating
MH  - Herpesvirus 6, Human/isolation & purification/*physiology
MH  - Humans
MH  - Interleukin-1/genetics
MH  - Interleukin-8/*genetics
MH  - Molecular Sequence Data
MH  - RNA, Messenger
MH  - Tumor Cells, Cultured
MH  - Ultraviolet Rays
MH  - Up-Regulation
MH  - Virus Replication
EDAT- 1996/05/01 00:00
MHDA- 2000/06/20 09:00
CRDT- 1996/05/01 00:00
PHST- 1996/05/01 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1996/05/01 00:00 [entrez]
AID - 10.1002/(SICI)1096-9071(199605)49:1<34::AID-JMV6>3.0.CO;2-L [pii]
AID - 10.1002/(SICI)1096-9071(199605)49:1<34::AID-JMV6>3.0.CO;2-L [doi]
PST - ppublish
SO  - J Med Virol. 1996 May;49(1):34-40. doi: 
      10.1002/(SICI)1096-9071(199605)49:1<34::AID-JMV6>3.0.CO;2-L.